{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Devi A"],"pubmed_abstract":["Although many phenotypic traits are determined by a large number of genetic variants, how a polygenic trait adapts in response to a change in the environment is not completely understood. In the framework of diffusion theory, we study the steady state and the adaptation dynamics of a large but finite population evolving under stabilizing selection and symmetric mutations when selection and mutation are moderately large. We find that in the stationary state, the allele frequency distribution at a locus is unimodal if its effect size is below a threshold effect and bimodal otherwise; these results are the stochastic analog of the deterministic ones where the stable allele frequency becomes bistable when the effect size exceeds a threshold. It is known that following a sudden shift in the phe"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.01.25.525607"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9901025"],"repository":["biostudies-literature"],"pubmed_title":["Polygenic adaptation dynamics in large, finite populations."],"pmcid":["PMC9901025"],"pubmed_authors":["Devi A","Jain K"],"additional_accession":[]},"is_claimable":false,"name":"Polygenic adaptation dynamics in large, finite populations.","description":"Although many phenotypic traits are determined by a large number of genetic variants, how a polygenic trait adapts in response to a change in the environment is not completely understood. In the framework of diffusion theory, we study the steady state and the adaptation dynamics of a large but finite population evolving under stabilizing selection and symmetric mutations when selection and mutation are moderately large. We find that in the stationary state, the allele frequency distribution at a locus is unimodal if its effect size is below a threshold effect and bimodal otherwise; these results are the stochastic analog of the deterministic ones where the stable allele frequency becomes bistable when the effect size exceeds a threshold. It is known that following a sudden shift in the phe","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T10:58:23.846Z","creation":"2025-04-04T10:58:23.846Z"},"accession":"S-EPMC9901025","cross_references":{"pubmed":["36747829"],"doi":["10.1101/2023.01.25.525607"]}}