{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(7)"],"submitter":["Qin X"],"pubmed_abstract":["Herein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams <i>via</i> DBU catalysis has been developed. The substrates were well-tolerated with high regio- and diastereoselectivities in moderate to good yields (32 examples). The control experiments revealed that the hydrogen of the amide was the key factor."],"journal":["RSC advances"],"pagination":["4782-4786"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9901288"],"repository":["biostudies-literature"],"pubmed_title":["Highly regioselective synthesis of lactams <i>via</i> cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst."],"pmcid":["PMC9901288"],"pubmed_authors":["Zhang W","Liu H","Yang Y","Zhang J","Qin X","Wang ZY","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Highly regioselective synthesis of lactams <i>via</i> cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst.","description":"Herein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams <i>via</i> DBU catalysis has been developed. The substrates were well-tolerated with high regio- and diastereoselectivities in moderate to good yields (32 examples). The control experiments revealed that the hydrogen of the amide was the key factor.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-18T21:16:55.102Z","creation":"2025-04-07T09:17:05.838Z"},"accession":"S-EPMC9901288","cross_references":{"pubmed":["36760281"],"doi":["10.1039/d2ra07117g"]}}