biostudies-literatureUnknown13(7)Qin XHerein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams <i>via</i> DBU catalysis has been developed. The substrates were well-tolerated with high regio- and diastereoselectivities in moderate to good yields (32 examples). The control experiments revealed that the hydrogen of the amide was the key factor.RSC advances4782-4786https://www.ebi.ac.uk/biostudies/studies/S-EPMC9901288biostudies-literatureHighly regioselective synthesis of lactams <i>via</i> cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst.PMC9901288Zhang WLiu HYang YZhang JQin XWang ZYSong YfalseHighly regioselective synthesis of lactams <i>via</i> cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst.Herein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams <i>via</i> DBU catalysis has been developed. The substrates were well-tolerated with high regio- and diastereoselectivities in moderate to good yields (32 examples). The control experiments revealed that the hydrogen of the amide was the key factor.2023-01-01T00:00:00Z2023 Jan2025-04-18T21:16:55.102Z2025-04-07T09:17:05.838ZS-EPMC99012883676028110.1039/d2ra07117g