biostudies-literatureUnknown28(1)Mirrahimi B<h4>Objective</h4>To evaluate the effects of dietary eicosapentaenoic acid (EPA) in children with atopic dermatitis.<h4>Methods</h4>Forty-eight children with atopic dermatitis were randomly allocated to receive either 250 mg twice daily EPA (n = 24) or placebo (n = 24) for 4 weeks. The absolute improvement in the SCORing Atopic Dermatitis (SCORAD) index and the necessity to use topical corticosteroids was evaluated.<h4>Results</h4>Based on an intention-to-treat analysis, after 2 weeks the scores decreased to 30.50 ± 8.91 and 38.34 ± 10.52 in the EPA and placebo groups, respectively (p = 0.015). Per-protocol analysis showed a decrease in scores to 18.01 ± 10.63 in the EPA group and to 30.11 ± 9.58 in the placebo group (p = 0.001). After 2 weeks, corticosteroid was needed in 11 (50.0%) patieThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG29-35https://www.ebi.ac.uk/biostudies/studies/S-EPMC9901318biostudies-literatureEvaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.PMC9901318Mohebbi RMirrahimi BMoazemi MJamshidi EEsmaily HMir MEslami NfalseEvaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.<h4>Objective</h4>To evaluate the effects of dietary eicosapentaenoic acid (EPA) in children with atopic dermatitis.<h4>Methods</h4>Forty-eight children with atopic dermatitis were randomly allocated to receive either 250 mg twice daily EPA (n = 24) or placebo (n = 24) for 4 weeks. The absolute improvement in the SCORing Atopic Dermatitis (SCORAD) index and the necessity to use topical corticosteroids was evaluated.<h4>Results</h4>Based on an intention-to-treat analysis, after 2 weeks the scores decreased to 30.50 ± 8.91 and 38.34 ± 10.52 in the EPA and placebo groups, respectively (p = 0.015). Per-protocol analysis showed a decrease in scores to 18.01 ± 10.63 in the EPA group and to 30.11 ± 9.58 in the placebo group (p = 0.001). After 2 weeks, corticosteroid was needed in 11 (50.0%) patie2023-01-01T00:00:00Z20232025-04-25T19:18:23.877Z2024-10-18T03:12:44.443ZS-EPMC99013183677798010.5863/1551-6776-28.1.29