{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Seo DO"],"funding":["NIA NIH HHS","NIDDK NIH HHS","NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["eadd1236"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9901565"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["379(6628)"],"pubmed_abstract":["Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease. Primary tauopathies are characterized by pathological tau accumulation and neuronal and synaptic loss. Apolipoprotein E (ApoE)-mediated neuroinflammation is involved in the progression of tau-mediated neurodegeneration, and emerging evidence suggests that the gut microbiota regulates neuroinflammation in an APOE genotype-dependent manner. However, evidence of a causal link between the microbiota and tau-mediated neurodegeneration is lacking. In this study, we characterized a genetically engineered mouse model of tauopathy expressing human ApoE isoforms reared under germ-free conditions or after perturbation of their gut microbiota with antibiotics. Both of these manipulations reduced gliosis, tau pathology, and neurodegeneration in a sex- and ApoE isoform-dependent manner. The findings reveal mechanistic and translationally relevant interrelationships between the microbiota, neuroinflammation, and tau-mediated neurodegeneration."],"journal":["Science (New York, N.Y.)"],"pubmed_title":["ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy."],"pmcid":["PMC9901565"],"funding_grant_id":["RF1 NS090934","P30 AG066444","T32 GM007200","P30 DK042086","R01 NS090934"],"pubmed_authors":["Lelwala-Guruge J","Lemieux M","Deng S","Sisodia SS","Karlsson M","Jain N","Handley SA","Franke E","Bao X","Dodiya H","Holtzman DM","Seo DO","Ulrich JD","Herz J","Gordon JI","O'Donnell D","Li Y","Kipnis J","Hu H","Serrano JR","Meier M","Desai C","Cheng J"],"additional_accession":[]},"is_claimable":false,"name":"ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy.","description":"Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease. Primary tauopathies are characterized by pathological tau accumulation and neuronal and synaptic loss. Apolipoprotein E (ApoE)-mediated neuroinflammation is involved in the progression of tau-mediated neurodegeneration, and emerging evidence suggests that the gut microbiota regulates neuroinflammation in an APOE genotype-dependent manner. However, evidence of a causal link between the microbiota and tau-mediated neurodegeneration is lacking. In this study, we characterized a genetically engineered mouse model of tauopathy expressing human ApoE isoforms reared under germ-free conditions or after perturbation of their gut microbiota with antibiotics. Both of these manipulations reduced gliosis, tau pathology, and neurodegeneration in a sex- and ApoE isoform-dependent manner. The findings reveal mechanistic and translationally relevant interrelationships between the microbiota, neuroinflammation, and tau-mediated neurodegeneration.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2024-11-13T21:05:53.9Z","creation":"2024-11-13T21:05:53.9Z"},"accession":"S-EPMC9901565","cross_references":{"pubmed":["36634180"],"doi":["10.1126/science.add1236"]}}