{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fung HY"],"funding":["NIAID NIH HHS","NCI NIH HHS"],"pagination":["eabl9925"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9901738"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(77)"],"pubmed_abstract":["Tissue-resident memory T (T<sub>RM</sub>) cells remain poised in the tissue and mediate robust protection from secondary infection. T<sub>RM</sub> cells within the intestine and other tissues are heterogeneous in their phenotype and function; however, the contributions of these T<sub>RM</sub> subsets to secondary infection remain poorly defined. To address the plasticity of intestinal T<sub>RM</sub> subsets and their role in local and systemic immunity, we generated mice to fate map intestinal CD103<sup>+</sup> T<sub>RM</sub> cells and track their location and function during secondary infection with <i>Yersinia pseudotuberculosis</i>. We found that CD103<sup>+</sup> T<sub>RM</sub> cells remained lodged in the tissue and were poorly reactivated during secondary challenge. CD103<sup>-</sup>"],"journal":["Science immunology"],"pubmed_title":["CD103 fate mapping reveals that intestinal CD103<sup>-</sup> tissue-resident memory T cells are the primary responders to secondary infection."],"pmcid":["PMC9901738"],"funding_grant_id":["P30 CA072720","R01 AI153096","R21 AI148900"],"pubmed_authors":["Fung HY","Teryek M","Lemenze AD","Bergsbaken T"],"additional_accession":[]},"is_claimable":false,"name":"CD103 fate mapping reveals that intestinal CD103<sup>-</sup> tissue-resident memory T cells are the primary responders to secondary infection.","description":"Tissue-resident memory T (T<sub>RM</sub>) cells remain poised in the tissue and mediate robust protection from secondary infection. T<sub>RM</sub> cells within the intestine and other tissues are heterogeneous in their phenotype and function; however, the contributions of these T<sub>RM</sub> subsets to secondary infection remain poorly defined. To address the plasticity of intestinal T<sub>RM</sub> subsets and their role in local and systemic immunity, we generated mice to fate map intestinal CD103<sup>+</sup> T<sub>RM</sub> cells and track their location and function during secondary infection with <i>Yersinia pseudotuberculosis</i>. We found that CD103<sup>+</sup> T<sub>RM</sub> cells remained lodged in the tissue and were poorly reactivated during secondary challenge. CD103<sup>-</sup>","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-26T22:55:23.758Z","creation":"2025-04-06T17:24:16.753Z"},"accession":"S-EPMC9901738","cross_references":{"pubmed":["36332012"],"doi":["10.1126/sciimmunol.abl9925"]}}