{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nishiwada S"],"funding":["Foundation for the National Institutes of Health","NCI NIH HHS"],"pagination":["321-330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9902480"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["128(2)"],"pubmed_abstract":["<h4>Background</h4>The adhesion G-protein-coupled receptors (GPCRs) play crucial roles in tumour pathogenesis, however, their clinical significance in pancreatic ductal adenocarcinoma (PDAC) remains unclear.<h4>Methods</h4>We analysed 796 PDAC patients, including 331 from public data sets (TCGA, ICGC and GSE57495) and 465 from independent cohorts (training: n = 321, validation: n = 144). Using in-vitro studies, we confirmed the biological function of the candidate GPCRs.<h4>Results</h4>Analysis of all 33 adhesion GPCRs, led to identify GPR115, as the only significant prognostic factor in all public data sets. The patients with high GPR115 expression exhibited significantly poorer prognosis for OS and RFS, in training (P < 0.01, P < 0.01) and validation cohort (P < 0.01, P = 0.04). Multivar"],"journal":["British journal of cancer"],"pubmed_title":["Clinical significance and functional role of adhesion G-protein-coupled receptors in human pancreatic ductal adenocarcinoma."],"pmcid":["PMC9902480"],"funding_grant_id":["R01 CA072851","U01 CA187956","CA72851, CA187956, CA202797 and CA214254","R01 CA202797","U01 CA214254"],"pubmed_authors":["Shimura T","Nakagawa K","Goel A","Terai T","Nakamura K","Sho M","Yamamura K","Yamada S","Nishiwada S","Kodera Y","Nagai M","Fujii T"],"additional_accession":[]},"is_claimable":false,"name":"Clinical significance and functional role of adhesion G-protein-coupled receptors in human pancreatic ductal adenocarcinoma.","description":"<h4>Background</h4>The adhesion G-protein-coupled receptors (GPCRs) play crucial roles in tumour pathogenesis, however, their clinical significance in pancreatic ductal adenocarcinoma (PDAC) remains unclear.<h4>Methods</h4>We analysed 796 PDAC patients, including 331 from public data sets (TCGA, ICGC and GSE57495) and 465 from independent cohorts (training: n = 321, validation: n = 144). Using in-vitro studies, we confirmed the biological function of the candidate GPCRs.<h4>Results</h4>Analysis of all 33 adhesion GPCRs, led to identify GPR115, as the only significant prognostic factor in all public data sets. The patients with high GPR115 expression exhibited significantly poorer prognosis for OS and RFS, in training (P < 0.01, P < 0.01) and validation cohort (P < 0.01, P = 0.04). Multivar","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-28T15:42:24.406Z","creation":"2025-04-06T02:39:35.913Z"},"accession":"S-EPMC9902480","cross_references":{"pubmed":["36396823"],"doi":["10.1038/s41416-022-02057-1"]}}