biostudies-literatureUnknown13(8)Zhang CAn unprecedented metal-free regioselective halogenation of 2<i>H</i>-indazoles has been revealed, which not only realized the highly selective synthesis of mono-halogenated products, but also completed poly-halogenations by fine tuning the reaction conditions. Various mono-/poly-/hetero-halogenated indazoles were obtained in moderate to excellent yields. Notably, this approach features environmentally friendly solvents, mild reaction conditions, simple execution and short reaction time.RSC advances4958-4962https://www.ebi.ac.uk/biostudies/studies/S-EPMC9904359biostudies-literatureMetal-free regioselective mono- and poly-halogenation of 2-substituted indazoles.PMC9904359Ding YXie YWei TZhang CYu ZSu WfalseMetal-free regioselective mono- and poly-halogenation of 2-substituted indazoles.An unprecedented metal-free regioselective halogenation of 2<i>H</i>-indazoles has been revealed, which not only realized the highly selective synthesis of mono-halogenated products, but also completed poly-halogenations by fine tuning the reaction conditions. Various mono-/poly-/hetero-halogenated indazoles were obtained in moderate to excellent yields. Notably, this approach features environmentally friendly solvents, mild reaction conditions, simple execution and short reaction time.2023-01-01T00:00:00Z2023 Feb2025-04-18T21:16:37.147Z2025-04-07T09:15:56.119ZS-EPMC99043593676209110.1039/d2ra07398f