{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garratt M"],"funding":["National Institute for Aging","Deutsche Forschungsgemeinschaft","NIA NIH HHS","Glenn Foundation for Medical Research"],"pagination":["e84060"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9904757"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Several previous lines of research have suggested, indirectly, that mouse lifespan is particularly susceptible to endocrine or nutritional signals in the first few weeks of life, as tested by manipulations of litter size, growth hormone levels, or mutations with effects specifically on early-life growth rate. The pace of early development in mice can also be influenced by exposure of nursing and weanling mice to olfactory cues. In particular, odors of same-sex adult mice can in some circumstances delay maturation. We hypothesized that olfactory information might also have a sex-specific effect on lifespan, and we show here that the lifespan of female mice can be increased significantly by odors from adult females administered transiently, that is from 3 days until 60 days of age. Female li"],"journal":["eLife"],"pubmed_title":["Lifespan extension in female mice by early, transient exposure to adult female olfactory cues."],"pmcid":["PMC9904757"],"funding_grant_id":["SFB/TRR 152","R37 AG051649","R01 AG051649","AG024824","SFB 894","R01 AG030593","P30 AG024824"],"pubmed_authors":["Pletcher SD","Leinders-Zufall T","Zufall F","Miller RA","Garratt M","Erturk I","Alonzo R"],"additional_accession":[]},"is_claimable":false,"name":"Lifespan extension in female mice by early, transient exposure to adult female olfactory cues.","description":"Several previous lines of research have suggested, indirectly, that mouse lifespan is particularly susceptible to endocrine or nutritional signals in the first few weeks of life, as tested by manipulations of litter size, growth hormone levels, or mutations with effects specifically on early-life growth rate. The pace of early development in mice can also be influenced by exposure of nursing and weanling mice to olfactory cues. In particular, odors of same-sex adult mice can in some circumstances delay maturation. We hypothesized that olfactory information might also have a sex-specific effect on lifespan, and we show here that the lifespan of female mice can be increased significantly by odors from adult females administered transiently, that is from 3 days until 60 days of age. Female li","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-03-18T13:50:01.421Z","creation":"2025-04-20T03:42:15.005Z"},"accession":"S-EPMC9904757","cross_references":{"pubmed":["36525360"],"doi":["10.7554/eLife.84060"]}}