{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hirz T"],"funding":["European Research Council","NIDDK NIH HHS","NHLBI NIH HHS","NCI NIH HHS"],"pagination":["663"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9905093"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["The treatment of low-risk primary prostate cancer entails active surveillance only, while high-risk disease requires multimodal treatment including surgery, radiation therapy, and hormonal therapy. Recurrence and development of metastatic disease remains a clinical problem, without a clear understanding of what drives immune escape and tumor progression. Here, we comprehensively describe the tumor microenvironment of localized prostate cancer in comparison with adjacent normal samples and healthy controls. Single-cell RNA sequencing and high-resolution spatial transcriptomic analyses reveal tumor context dependent changes in gene expression. Our data indicate that an immune suppressive tumor microenvironment associates with suppressive myeloid populations and exhausted T-cells, in addition to high stromal angiogenic activity. We infer cell-to-cell relationships from high throughput ligand-receptor interaction measurements within undissociated tissue sections. Our work thus provides a highly detailed and comprehensive resource of the prostate tumor microenvironment as well as tumor-stromal cell interactions."],"journal":["Nature communications"],"pubmed_title":["Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses."],"pmcid":["PMC9905093"],"funding_grant_id":["856529","P30 CA006516","U54 CA163191","R24 DK103074","R01 CA193481","R01 HL131768"],"pubmed_authors":["Kfoury Y","Sykes DB","Hirz T","Mei S","Chen F","Wszolek MW","Salari K","Dahl DM","Baryawno N","Wu CL","Murray E","Sarkar H","Wu S","Verhoeven BM","Scadden DT","Saylor PJ","Kharchenko PV","Zlatev DV","Subtelny AO","Macosko EZ"],"additional_accession":[]},"is_claimable":false,"name":"Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses.","description":"The treatment of low-risk primary prostate cancer entails active surveillance only, while high-risk disease requires multimodal treatment including surgery, radiation therapy, and hormonal therapy. Recurrence and development of metastatic disease remains a clinical problem, without a clear understanding of what drives immune escape and tumor progression. Here, we comprehensively describe the tumor microenvironment of localized prostate cancer in comparison with adjacent normal samples and healthy controls. Single-cell RNA sequencing and high-resolution spatial transcriptomic analyses reveal tumor context dependent changes in gene expression. Our data indicate that an immune suppressive tumor microenvironment associates with suppressive myeloid populations and exhausted T-cells, in addition to high stromal angiogenic activity. We infer cell-to-cell relationships from high throughput ligand-receptor interaction measurements within undissociated tissue sections. Our work thus provides a highly detailed and comprehensive resource of the prostate tumor microenvironment as well as tumor-stromal cell interactions.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-06-24T03:12:50.74Z","creation":"2025-04-04T11:50:25.461Z"},"accession":"S-EPMC9905093","cross_references":{"pubmed":["36750562"],"doi":["10.1038/s41467-023-36325-2"]}}