biostudies-literatureLi HNIA NIH HHS977-987https://www.ebi.ac.uk/biostudies/studies/S-EPMC9905310biostudies-literatureUnknown91(3)<h4>Background</h4>Alzheimer's disease (AD) is a common neurodegenerative disease and mild cognitive impairment (MCI) is considered as the prodromal stage of AD. Previous studies showed that changes in the neurotrophin signaling pathway could lead to cognitive decline in AD. However, the association of single nucleotide polymorphisms (SNPs) in genes that are involved in this pathway with AD progression from MCI remains unclear.<h4>Objective</h4>We investigated the associations between SNPs involved in the neurotrophin signaling pathway with AD progression.<h4>Methods</h4>We performed single-locus analysis to identify neurotrophin-signaling-related SNPs associated with the AD progression using 767 patients from the Alzheimer's Disease Neuroimaging Initiative study and 1,373 patients from thJournal of Alzheimer's disease : JADNovel Genetic Variants in TP37, PIK3R1, CALM1, and PLCG2 of the Neurotrophin Signaling Pathway Are Associated with the Progression from Mild Cognitive Impairment to Alzheimer's Disease.PMC9905310P30 AG013846P30 AG028383P30 AG008017P30 AG053760P30 AG010133R01 AG064803P50 AG005146P50 AG005681P50 AG005142P30 AG062715P50 AG047366P50 AG047266P30 AG019610P50 AG023501P30 AG008051P30 AG010129P30 AG013854P30 AG072958P50 AG005138P30 AG062428P50 AG008702P30 AG010124P30 AG012300U01 AG016976P50 AG047270P30 AG062421P50 AG005136P50 AG025688P30 AG035982P30 AG062422P30 AG010161P50 AG005133P30 AG062429P30 AG028716P30 AG049638U24 AG072122U01 AG024904P50 AG016573P30 AG072947Liu HLutz MWLi HLuo SAlzheimer’s Disease Neuroimaging InitiativefalseNovel Genetic Variants in TP37, PIK3R1, CALM1, and PLCG2 of the Neurotrophin Signaling Pathway Are Associated with the Progression from Mild Cognitive Impairment to Alzheimer's Disease.<h4>Background</h4>Alzheimer's disease (AD) is a common neurodegenerative disease and mild cognitive impairment (MCI) is considered as the prodromal stage of AD. Previous studies showed that changes in the neurotrophin signaling pathway could lead to cognitive decline in AD. However, the association of single nucleotide polymorphisms (SNPs) in genes that are involved in this pathway with AD progression from MCI remains unclear.<h4>Objective</h4>We investigated the associations between SNPs involved in the neurotrophin signaling pathway with AD progression.<h4>Methods</h4>We performed single-locus analysis to identify neurotrophin-signaling-related SNPs associated with the AD progression using 767 patients from the Alzheimer's Disease Neuroimaging Initiative study and 1,373 patients from th2023-01-01T00:00:00Z20232026-05-28T08:03:46.985Z2025-04-04T08:34:54.487ZS-EPMC99053103653008310.3233/jad-22068010.3233/JAD-220680