{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Bjornestad SA"],"funding":["Universitetet i Oslo"],"pubmed_abstract":["Major histocompatibility complex (MHC) class I and II are crucial for the adaptive immune system because they are involved in peptide presentation to T cells. Until recently, it was believed that MHC genes and their associated immune components had been conserved since their evolutionary emergence in jawed fish. However, sequencing of the Atlantic cod (<i>Gadus morhua</i>) genome revealed a loss of MHC class II genes, and an extreme expansion of MHC class I genes. These findings lead to the hypothesis that a loss of the MHC class II pathway coincided with a more versatile use of MHC class I, but so far there is no direct experimental evidence in support of this. To gain a deeper understanding of the function of the expanded MHC class I, we selected five MHC class I gene variants representi"],"journal":["Frontiers in cell and developmental biology"],"pagination":["1050323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9905690"],"repository":["biostudies-literature"],"pubmed_title":["Atlantic cod (<i>Gadus morhua</i>) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals."],"pmcid":["PMC9905690"],"pubmed_authors":["Bakke O","Jentoft S","Solbakken MH","Progida C","Jakobsen KS","Bjornestad SA"],"additional_accession":[]},"is_claimable":false,"name":"Atlantic cod (<i>Gadus morhua</i>) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals.","description":"Major histocompatibility complex (MHC) class I and II are crucial for the adaptive immune system because they are involved in peptide presentation to T cells. Until recently, it was believed that MHC genes and their associated immune components had been conserved since their evolutionary emergence in jawed fish. However, sequencing of the Atlantic cod (<i>Gadus morhua</i>) genome revealed a loss of MHC class II genes, and an extreme expansion of MHC class I genes. These findings lead to the hypothesis that a loss of the MHC class II pathway coincided with a more versatile use of MHC class I, but so far there is no direct experimental evidence in support of this. To gain a deeper understanding of the function of the expanded MHC class I, we selected five MHC class I gene variants representi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-28T11:51:43.156Z","creation":"2025-04-07T03:20:06.484Z"},"accession":"S-EPMC9905690","cross_references":{"pubmed":["36760361"],"doi":["10.3389/fcell.2023.1050323"]}}