biostudies-literatureKong XTianjin Science and Technology ProgramChinese Academy of Medical SciencesNational Natural Science Foundation of ChinaTianjin Municipal Bureau of Public Health1045697https://www.ebi.ac.uk/biostudies/studies/S-EPMC9905717biostudies-literatureUnknown11<b>Objective:</b> The issue of when to start treatment in patients with hyperuricemia (HUA) without gout and chronic kidney disease (CKD) is both important and controversial. In this study, Raman spectroscopy (RS) was used to analyze urine samples, and key genes expressed differentially CKD were identified using bioinformatics. The biological functions and regulatory pathways of these key genes were preliminarily analyzed, and the relationship between them as well as the heterogeneity of the urine components of HUA was evaluated. This study provides new ideas for the rapid evaluation of renal function in patients with HUA and CKD, while providing an important reference for the new treatment strategy of HUA disease. <b>Methods:</b> A physically examined population in 2021 was recruited as tFrontiers in chemistryRapid identification of early renal damage in asymptomatic hyperuricemia patients based on urine Raman spectroscopy and bioinformatics analysis.PMC990571721JCZDJC00940TJWJ2022XK001 TJYXZDXK-006A2022-I2M-JB-01592163213 81970085Bai SLiang HMiao YAn WWang HQiang JZhou YKong XZhang QfalseRapid identification of early renal damage in asymptomatic hyperuricemia patients based on urine Raman spectroscopy and bioinformatics analysis.<b>Objective:</b> The issue of when to start treatment in patients with hyperuricemia (HUA) without gout and chronic kidney disease (CKD) is both important and controversial. In this study, Raman spectroscopy (RS) was used to analyze urine samples, and key genes expressed differentially CKD were identified using bioinformatics. The biological functions and regulatory pathways of these key genes were preliminarily analyzed, and the relationship between them as well as the heterogeneity of the urine components of HUA was evaluated. This study provides new ideas for the rapid evaluation of renal function in patients with HUA and CKD, while providing an important reference for the new treatment strategy of HUA disease. <b>Methods:</b> A physically examined population in 2021 was recruited as t2023-01-01T00:00:00Z20232026-07-14T19:03:45.946Z2024-11-20T00:52:58.149ZS-EPMC99057173676219410.3389/fchem.2023.1045697