biostudies-literatureChen XNatural Science Foundation of Anhui Province of China129https://www.ebi.ac.uk/biostudies/studies/S-EPMC9905770biostudies-literatureUnknown23(1)<h4>Background</h4>The tumor microenvironment (TME) in breast cancer plays a vital role in occurrence, development, and therapeutic responses. However, immune and stroma constituents in the TME are major obstacles to understanding and treating breast cancer. We evaluated the significance of TME-related genes in breast cancer.<h4>Methods</h4>Invasive breast cancer (BRCA) samples were retrieved from the TCGA and GEO databases. Stroma and immune scores of samples as well as the proportion of tumor infiltrating immune cells (TICs) were calculated using the ESTIMATE and CIBERSORT algorithms. TME-related differentially expressed genes (DEGs) were analyzed by a protein interaction (PPI) network and univariate Cox regression to determine CD1C as a hub gene. Subsequently, the prognostic value of CDBMC cancerCD1C is associated with breast cancer prognosis and immune infiltrates.PMC9905770Grant no.2008085QC112Li JYang LZhang JZhang LZhang SLi WDing YLei XZheng LJia WChen XTang TShi JfalseCD1C is associated with breast cancer prognosis and immune infiltrates.<h4>Background</h4>The tumor microenvironment (TME) in breast cancer plays a vital role in occurrence, development, and therapeutic responses. However, immune and stroma constituents in the TME are major obstacles to understanding and treating breast cancer. We evaluated the significance of TME-related genes in breast cancer.<h4>Methods</h4>Invasive breast cancer (BRCA) samples were retrieved from the TCGA and GEO databases. Stroma and immune scores of samples as well as the proportion of tumor infiltrating immune cells (TICs) were calculated using the ESTIMATE and CIBERSORT algorithms. TME-related differentially expressed genes (DEGs) were analyzed by a protein interaction (PPI) network and univariate Cox regression to determine CD1C as a hub gene. Subsequently, the prognostic value of CD2023-01-01T00:00:00Z2023 Feb2025-04-22T10:00:58.03Z2025-04-05T23:24:38.083ZS-EPMC99057703675525910.1186/s12885-023-10558-2