biostudies-literatureUnknown14Khan IThe <i>WRKY</i> and <i>bHLH</i> transcription factors have been implicated in the regulation of gene expression during various physiological processes in plants, especially in plant stress responses. However, little information about the heavy metal-responsive <i>SlWRKY</i> and <i>SlbHLH</i> in tomato (<i>Solanum lycopersicum</i>) is available. We performed a genome-wide investigation for these two TF families in <i>S. lycopersicum</i> and determined their role in cadmium (Cd) stress tolerance. Furthermore, ortholog analysis with the <i>Arabidopsis</i> genome led to classifying <i>WRKY</i> and <i>bHLH</i> ortholog genes into nine and 11 clusters, respectively. The comparative phylogenetic analysis revealed duplication events and gene loss in <i>Arabidopsis</i> and <i>S. lycopersicum</i>, wFrontiers in plant science1100895https://www.ebi.ac.uk/biostudies/studies/S-EPMC9905835biostudies-literatureGenome-wide annotation and expression analysis of <i>WRKY</i> and <i>bHLH</i> transcriptional factor families reveal their involvement under cadmium stress in tomato (<i>Solanum lycopersicum</i> L.).PMC9905835Khan IAl-Harrasi ABilal SKhan ALKim KMAsaf SJan RLubnafalseGenome-wide annotation and expression analysis of <i>WRKY</i> and <i>bHLH</i> transcriptional factor families reveal their involvement under cadmium stress in tomato (<i>Solanum lycopersicum</i> L.).The <i>WRKY</i> and <i>bHLH</i> transcription factors have been implicated in the regulation of gene expression during various physiological processes in plants, especially in plant stress responses. However, little information about the heavy metal-responsive <i>SlWRKY</i> and <i>SlbHLH</i> in tomato (<i>Solanum lycopersicum</i>) is available. We performed a genome-wide investigation for these two TF families in <i>S. lycopersicum</i> and determined their role in cadmium (Cd) stress tolerance. Furthermore, ortholog analysis with the <i>Arabidopsis</i> genome led to classifying <i>WRKY</i> and <i>bHLH</i> ortholog genes into nine and 11 clusters, respectively. The comparative phylogenetic analysis revealed duplication events and gene loss in <i>Arabidopsis</i> and <i>S. lycopersicum</i>, w2023-01-01T00:00:00Z20232026-06-23T03:18:59.062Z2024-12-03T18:06:30.496ZS-EPMC99058353676063210.3389/fpls.2023.1100895