{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(2)"],"submitter":["Kawarasaki T"],"pubmed_abstract":["The ubiquitin-specific chaperone AAA-ATPase Cdc48 and its orthologs p97/valosin-containing protein (VCP) in mammals play crucial roles in regulating numerous intracellular pathways via segregase activity, which separates polyubiquitinated targets from membranes or binding partners. Interestingly, high-throughput experiments show that a vast number of metabolic enzymes are modified with ubiquitin. Therefore, Cdc48 may regulate metabolic pathways, for example by acting on the polyubiquitin chains of metabolic enzymes; however, the role of Cdc48 in metabolic regulation remains largely unknown. To begin to analyze the role of Cdc48 in metabolic regulation in yeast, we performed a metabolomics analysis of temperature-sensitive <i>cdc48-3</i> mutant cells. We found that the amount of metabolites"],"journal":["Heliyon"],"pagination":["e13219"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9905943"],"repository":["biostudies-literature"],"pubmed_title":["Metabolomics analysis of an AAA-ATPase Cdc48-deficient yeast strain."],"pmcid":["PMC9905943"],"pubmed_authors":["Kawarasaki T","Nakatsukasa K"],"additional_accession":[]},"is_claimable":false,"name":"Metabolomics analysis of an AAA-ATPase Cdc48-deficient yeast strain.","description":"The ubiquitin-specific chaperone AAA-ATPase Cdc48 and its orthologs p97/valosin-containing protein (VCP) in mammals play crucial roles in regulating numerous intracellular pathways via segregase activity, which separates polyubiquitinated targets from membranes or binding partners. Interestingly, high-throughput experiments show that a vast number of metabolic enzymes are modified with ubiquitin. Therefore, Cdc48 may regulate metabolic pathways, for example by acting on the polyubiquitin chains of metabolic enzymes; however, the role of Cdc48 in metabolic regulation remains largely unknown. To begin to analyze the role of Cdc48 in metabolic regulation in yeast, we performed a metabolomics analysis of temperature-sensitive <i>cdc48-3</i> mutant cells. We found that the amount of metabolites","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-18T21:16:42.007Z","creation":"2025-04-07T09:14:29.32Z"},"accession":"S-EPMC9905943","cross_references":{"pubmed":["36761826"],"doi":["10.1016/j.heliyon.2023.e13219"]}}