{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Murphy N"],"funding":["Cancer Council Victoria","Cancer Research UK","Surveillance, Epidemiology and End Results","Knut and Alice Wallenberg Foundation","National Institutes of Health","Swedish Research Council","NCI Cancer Center Support","National Cancer Institute of Canada","Canadian Institutes of Health Research","Insamlingsstiftelsen, both at Umeå University","Swedish Research Council and County Councils of Skåne and Västerbotten","U.S. Department of Health and Human Services","Interdisciplinary Health Research Team","NHS","National Cancer Institute","Fred Hutch funded by Office of Research Infrastructure Program","Spanish Association Against Cancer Scientific Foundation","NIH HHS","Victorian Cancer Registry","Australian Institute of Health and Welfare","German Research Council","VicHealth and Cancer Council Victoria","NHMRC","Lion&apos;s Cancer Research Foundation","NIH","National Death Index and the Australian Cancer Database","German Federal Ministry of Education and Research","CIHR","Scientific Computing Infrastructure","NCI","Lion's Cancer Research Foundation","Center for Inherited Disease Research","Swedish Cancer Society","NCI NIH HHS","Region Västerbotten","National Center for Tumor Diseases"],"pagination":["165-173"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9905970"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(2)"],"pubmed_abstract":["<h4>Background</h4>Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsistent across molecular subtypes of the disease.<h4>Methods</h4>We pooled data on body mass index (BMI), tumor microsatellite instability status, CpG island methylator phenotype status, BRAF and KRAS mutations, and Jass classification types for 11 872 CRC cases and 11 013 controls from 11 observational studies. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for covariables.<h4>Results</h4>Higher BMI was associated with increased CRC risk (OR per 5 kg/m2 = 1.18, 95% CI = 1.15 to 1.22). The positive association was stronger for men than women but similar across tumor subtypes defined by individual molecular markers. In analyses by Jass type, higher BMI was associated with elevated CRC risk for types 1-4 cases but not for type 5 CRC cases (considered familial-like/Lynch syndrome microsatellite instability-H, CpG island methylator phenotype-low or negative, BRAF-wild type, KRAS-wild type, OR = 1.04, 95% CI = 0.90 to 1.20). This pattern of associations for BMI and Jass types was consistent by sex and design of contributing studies (cohort or case-control).<h4>Conclusions</h4>In contrast to previous reports with fewer study participants, we found limited evidence of heterogeneity for the association between BMI and CRC risk according to molecular subtype, suggesting that obesity influences nearly all major pathways involved in colorectal carcinogenesis. The null association observed for the Jass type 5 suggests that BMI is not a risk factor for the development of CRC for individuals with Lynch syndrome."],"journal":["Journal of the National Cancer Institute"],"pubmed_title":["Body mass index and molecular subtypes of colorectal cancer."],"pmcid":["PMC9905970"],"funding_grant_id":["U01 CA137088","P01 CA087969","R01 CA143247","CH 117/1-1","509348","R01 CA151993","KL 2354/3-1","18223","PPRCPJT\\100005","18226","R01 CA137178","U01 CA122839","209057","VLL-765961","BR 1704/6-3","HE 5998/2-1","VR 2017-01737","BR 1704/6-1","S10OD028685","01ER0815","01ER0814","BR 1704/6-4","01ER1505B","UM1 CA186107","01ER1505A","R01 CA48998","VLL-841671","R35 CA197735","U01 CA167552","R01CA201407","U01 CA167551","HHSN268201700006I","VLL-833291","VR 2017-00650","251553","UM1 CA167552","504711","HHSN268201200008I","POSTD037OBÓN","CRT 43821","C18281/A29019","P01 CA055075","R01 CA059045","P30 CA015704","U01 CA 84968-06","RO 2270/8-1","CAN 2017/581","U01 CA74783","01KH0404","BR 1704/17-1","HO 5117/2-1"],"pubmed_authors":["Southey MC","Huang WY","Toland AE","Berndt SI","Lin Y","Schoen RE","Le Marchand L","Peters U","Chen X","Wang X","Gunter MJ","Harlid S","Chang-Claude J","Giannakis M","Steinfelder RS","Sun W","Van Guelpen B","Tsilidis KK","Gruber SB","Laskar RS","Papadimitriou N","Brenner H","Thibodeau SN","Newton CC","Sakoda LC","Hoffmeister M","Qu C","Trinh QM","Woods MO","Zaidi SH","Phipps AI","Farris AB","Murphy N","Song M","Gallinger S","Giles GG","Newcomb PA","Buchanan DD","Cheng I","Stadler ZK","Chan AT","Obon-Santacana M","French AJ","Ugai T","Mandic M","Ogino S","Harrison TA","Dimou N","Campbell PT","Cao Y","Jenkins MA","Hsu L","Drew D","Limburg P","Aglago EK","Georgeson P","Nowak JA"],"additional_accession":[]},"is_claimable":false,"name":"Body mass index and molecular subtypes of colorectal cancer.","description":"<h4>Background</h4>Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsistent across molecular subtypes of the disease.<h4>Methods</h4>We pooled data on body mass index (BMI), tumor microsatellite instability status, CpG island methylator phenotype status, BRAF and KRAS mutations, and Jass classification types for 11 872 CRC cases and 11 013 controls from 11 observational studies. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for covariables.<h4>Results</h4>Higher BMI was associated with increased CRC risk (OR per 5 kg/m2 = 1.18, 95% CI = 1.15 to 1.22). The positive association was stronger for men than women but similar across tumor subtypes defined by individual molecular markers. In analyses by Jass type, higher BMI was associated with elevated CRC risk for types 1-4 cases but not for type 5 CRC cases (considered familial-like/Lynch syndrome microsatellite instability-H, CpG island methylator phenotype-low or negative, BRAF-wild type, KRAS-wild type, OR = 1.04, 95% CI = 0.90 to 1.20). This pattern of associations for BMI and Jass types was consistent by sex and design of contributing studies (cohort or case-control).<h4>Conclusions</h4>In contrast to previous reports with fewer study participants, we found limited evidence of heterogeneity for the association between BMI and CRC risk according to molecular subtype, suggesting that obesity influences nearly all major pathways involved in colorectal carcinogenesis. The null association observed for the Jass type 5 suggests that BMI is not a risk factor for the development of CRC for individuals with Lynch syndrome.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T12:56:12.885Z","creation":"2025-04-04T12:56:12.885Z"},"accession":"S-EPMC9905970","cross_references":{"pubmed":["36445035"],"doi":["10.1093/jnci/djac215"]}}