{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(7)"],"submitter":["Al-Ghafry M"],"pubmed_abstract":["<h4>Background</h4>Adults infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have had high rates of thrombosis. A novel condition in children infected with SARS-CoV-2, multisystem inflammatory syndrome in children (MIS-C), has limited data on their prothrombotic state or need for thromboprophylaxis.<h4>Objectives</h4>We aimed to analyze the prothrombotic state using coagulation profiles, rotational thromboelastometry (ROTEM) parameters and clinical outcomes, to determine if this could aid in risk stratification for thromboprophylaxis.<h4>Methods</h4>This analysis included patients (<21 years of age) with a diagnosis of MIS-C (n = 40) and controls (presenting with suspicion of MIS-C but later ruled out; n = 26).<h4>Results</h4>MIS-C patients had higher levels of infl"],"journal":["Journal of thrombosis and haemostasis : JTH"],"pagination":["1764-1770"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9906141"],"repository":["biostudies-literature"],"pubmed_title":["Multisystem inflammatory syndrome in children (MIS-C) and the prothrombotic state: Coagulation profiles and rotational thromboelastometry in a MIS-C cohort."],"pmcid":["PMC9906141"],"pubmed_authors":["Misra N","Levine C","Vlachos A","Palumbo N","Lipton JM","Uster E","Shore-Lesserson L","Malik M","Acharya SS","Capone CA","Mitchell EC","Rajan S","Al-Ghafry M","Appiah-Kubi A","Wolfe LC","Vagrecha A","Aygun B"],"additional_accession":[]},"is_claimable":false,"name":"Multisystem inflammatory syndrome in children (MIS-C) and the prothrombotic state: Coagulation profiles and rotational thromboelastometry in a MIS-C cohort.","description":"<h4>Background</h4>Adults infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have had high rates of thrombosis. A novel condition in children infected with SARS-CoV-2, multisystem inflammatory syndrome in children (MIS-C), has limited data on their prothrombotic state or need for thromboprophylaxis.<h4>Objectives</h4>We aimed to analyze the prothrombotic state using coagulation profiles, rotational thromboelastometry (ROTEM) parameters and clinical outcomes, to determine if this could aid in risk stratification for thromboprophylaxis.<h4>Methods</h4>This analysis included patients (<21 years of age) with a diagnosis of MIS-C (n = 40) and controls (presenting with suspicion of MIS-C but later ruled out; n = 26).<h4>Results</h4>MIS-C patients had higher levels of infl","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2025-04-04T12:56:11.745Z","creation":"2025-04-04T12:56:11.745Z"},"accession":"S-EPMC9906141","cross_references":{"pubmed":["33872443"],"doi":["10.1111/jth.15340"]}}