biostudies-literatureUnknown19(7)Al-Ghafry M<h4>Background</h4>Adults infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have had high rates of thrombosis. A novel condition in children infected with SARS-CoV-2, multisystem inflammatory syndrome in children (MIS-C), has limited data on their prothrombotic state or need for thromboprophylaxis.<h4>Objectives</h4>We aimed to analyze the prothrombotic state using coagulation profiles, rotational thromboelastometry (ROTEM) parameters and clinical outcomes, to determine if this could aid in risk stratification for thromboprophylaxis.<h4>Methods</h4>This analysis included patients (<21 years of age) with a diagnosis of MIS-C (n = 40) and controls (presenting with suspicion of MIS-C but later ruled out; n = 26).<h4>Results</h4>MIS-C patients had higher levels of inflJournal of thrombosis and haemostasis : JTH1764-1770https://www.ebi.ac.uk/biostudies/studies/S-EPMC9906141biostudies-literatureMultisystem inflammatory syndrome in children (MIS-C) and the prothrombotic state: Coagulation profiles and rotational thromboelastometry in a MIS-C cohort.PMC9906141Misra NLevine CVlachos APalumbo NLipton JMUster EShore-Lesserson LMalik MAcharya SSCapone CAMitchell ECRajan SAl-Ghafry MAppiah-Kubi AWolfe LCVagrecha AAygun BfalseMultisystem inflammatory syndrome in children (MIS-C) and the prothrombotic state: Coagulation profiles and rotational thromboelastometry in a MIS-C cohort.<h4>Background</h4>Adults infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have had high rates of thrombosis. A novel condition in children infected with SARS-CoV-2, multisystem inflammatory syndrome in children (MIS-C), has limited data on their prothrombotic state or need for thromboprophylaxis.<h4>Objectives</h4>We aimed to analyze the prothrombotic state using coagulation profiles, rotational thromboelastometry (ROTEM) parameters and clinical outcomes, to determine if this could aid in risk stratification for thromboprophylaxis.<h4>Methods</h4>This analysis included patients (<21 years of age) with a diagnosis of MIS-C (n = 40) and controls (presenting with suspicion of MIS-C but later ruled out; n = 26).<h4>Results</h4>MIS-C patients had higher levels of infl2021-01-01T00:00:00Z2021 Jul2025-04-04T12:56:11.745Z2025-04-04T12:56:11.745ZS-EPMC99061413387244310.1111/jth.15340