{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gao QC"],"funding":["Natural Science Foundation of Hubei Province","South-Central University for Nationalities","National Natural Science Foundation of China"],"pagination":["100-106"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9907013"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19"],"pubmed_abstract":["Herein, we report an unprecedented Rh(III)-catalyzed C-H activation/annulation cascade of readily available enaminones with iodonium ylides towards the convenient synthesis of isocoumarins. This coupling system proceeds in useful chemical yields (up to 93%) via a cascade C-H activation, Rh-carbenoid migratory insertion and acid-promoted intramolecular annulation. The success of gram-scale reaction and diverse functionalization of isocoumarins demonstrated the synthetic utility of this protocol."],"journal":["Beilstein journal of organic chemistry"],"pubmed_title":["Practical synthesis of isocoumarins via Rh(III)-catalyzed C-H activation/annulation cascade."],"pmcid":["PMC9907013"],"funding_grant_id":["No. 21901258, 22271314, 21971001 and 21702001","YZZ19003","2021CFA022"],"pubmed_authors":["Hu XQ","Gao QC","Xuan J","Li YF"],"additional_accession":[]},"is_claimable":false,"name":"Practical synthesis of isocoumarins via Rh(III)-catalyzed C-H activation/annulation cascade.","description":"Herein, we report an unprecedented Rh(III)-catalyzed C-H activation/annulation cascade of readily available enaminones with iodonium ylides towards the convenient synthesis of isocoumarins. This coupling system proceeds in useful chemical yields (up to 93%) via a cascade C-H activation, Rh-carbenoid migratory insertion and acid-promoted intramolecular annulation. The success of gram-scale reaction and diverse functionalization of isocoumarins demonstrated the synthetic utility of this protocol.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-03-17T15:57:40.028Z","creation":"2025-04-04T18:44:05.771Z"},"accession":"S-EPMC9907013","cross_references":{"pubmed":["36761471"],"doi":["10.3762/bjoc.19.10"]}}