{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Raicu AM"],"funding":["NICHD NIH HHS","NHGRI NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["msad003"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9907507"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(2)"],"pubmed_abstract":["Evolution of sequence-specific transcription factors clearly drives lineage-specific innovations, but less is known about how changes in the central transcriptional machinery may contribute to evolutionary transformations. In particular, transcriptional regulators are rich in intrinsically disordered regions that appear to be magnets for evolutionary innovation. The C-terminal Binding Protein (CtBP) is a transcriptional corepressor derived from an ancestral lineage of alpha hydroxyacid dehydrogenases; it is found in mammals and invertebrates, and features a core NAD-binding domain as well as an unstructured C-terminus (CTD) of unknown function. CtBP can act on promoters and enhancers to repress transcription through chromatin-linked mechanisms. Our comparative phylogenetic study shows that"],"journal":["Molecular biology and evolution"],"pubmed_title":["The Cynosure of CtBP: Evolution of a Bilaterian Transcriptional Corepressor."],"pmcid":["PMC9907507"],"funding_grant_id":["F31 HD105410","T32 HG000040","R01 GM124137","F32 CA261115"],"pubmed_authors":["Arnosti DN","Niblock M","Raicu AM","Jain A","Yang Y","Kadiyala D","Bird KM","Siddiq M","Bertholf K","Seenivasan A"],"additional_accession":[]},"is_claimable":false,"name":"The Cynosure of CtBP: Evolution of a Bilaterian Transcriptional Corepressor.","description":"Evolution of sequence-specific transcription factors clearly drives lineage-specific innovations, but less is known about how changes in the central transcriptional machinery may contribute to evolutionary transformations. In particular, transcriptional regulators are rich in intrinsically disordered regions that appear to be magnets for evolutionary innovation. The C-terminal Binding Protein (CtBP) is a transcriptional corepressor derived from an ancestral lineage of alpha hydroxyacid dehydrogenases; it is found in mammals and invertebrates, and features a core NAD-binding domain as well as an unstructured C-terminus (CTD) of unknown function. CtBP can act on promoters and enhancers to repress transcription through chromatin-linked mechanisms. Our comparative phylogenetic study shows that","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-04-08T13:15:44.75Z","creation":"2025-04-19T02:46:47.539Z"},"accession":"S-EPMC9907507","cross_references":{"pubmed":["36625090"],"doi":["10.1093/molbev/msad003"]}}