biostudies-literatureKamau ADFIDGlobal HealthBill and Melinda Gates FoundationWellcome Truste875-e883https://www.ebi.ac.uk/biostudies/studies/S-EPMC9907553biostudies-literatureUnknown76(3)<h4>Background</h4>Intermittent preventive treatment (IPTp) for pregnant women with sulfadoxine-pyrimethamine (SP) is widely implemented for the prevention of malaria in pregnancy and adverse birth outcomes. The efficacy of SP is declining, and there are concerns that IPTp may have reduced impact in areas of high resistance. We sought to determine the protection afforded by SP as part of IPTp against adverse birth outcomes in an area with high levels of SP resistance on the Kenyan coast.<h4>Methods</h4>A secondary analysis of surveillance data on deliveries at the Kilifi County Hospital between 2015 and 2021 was undertaken in an area of low malaria transmission and high parasite mutations associated with SP resistance. A multivariable logistic regression model was developed to estimate theClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaImpact of Intermittent Presumptive Treatment for Malaria in Pregnancy on Hospital Birth Outcomes on the Kenyan Coast.PMC9907553203077Nyaguara ABerkley JAMusau MAmadi DMwakio SSeale ACBejon PKamau ASnow RWfalseImpact of Intermittent Presumptive Treatment for Malaria in Pregnancy on Hospital Birth Outcomes on the Kenyan Coast.<h4>Background</h4>Intermittent preventive treatment (IPTp) for pregnant women with sulfadoxine-pyrimethamine (SP) is widely implemented for the prevention of malaria in pregnancy and adverse birth outcomes. The efficacy of SP is declining, and there are concerns that IPTp may have reduced impact in areas of high resistance. We sought to determine the protection afforded by SP as part of IPTp against adverse birth outcomes in an area with high levels of SP resistance on the Kenyan coast.<h4>Methods</h4>A secondary analysis of surveillance data on deliveries at the Kilifi County Hospital between 2015 and 2021 was undertaken in an area of low malaria transmission and high parasite mutations associated with SP resistance. A multivariable logistic regression model was developed to estimate the2023-01-01T00:00:00Z2023 Feb2025-04-19T17:51:58.874Z2025-04-19T17:51:58.874ZS-EPMC99075533573185010.1093/cid/ciac509