biostudies-literatureZhang YNHLBI NIH HHSNational Institutes of Health100352https://www.ebi.ac.uk/biostudies/studies/S-EPMC9907788biostudies-literatureUnknown11Post-acute sequelae of SARS-CoV-2 infection (PASC) affects a wide range of organ systems among a large proportion of patients with SARS-CoV-2 infection. Although studies have identified a broad set of patient-level risk factors for PASC, little is known about the association between "exposome"-the totality of environmental exposures and the risk of PASC. Using electronic health data of patients with COVID-19 from two large clinical research networks in New York City and Florida, we identified environmental risk factors for 23 PASC symptoms and conditions from nearly 200 exposome factors. The three domains of exposome include natural environment, built environment, and social environment. We conducted a two-phase environment-wide association study. In Phase 1, we ran a mixed effects logistiEnvironmental advancesIdentifying environmental risk factors for post-acute sequelae of SARS-CoV-2 infection: An EHR-based cohort study from the recover program.PMC9907788EHR-01–21OT2HL161847OT2 HL161847Fokaidis VHall JWeiner MGCarton TWWang FWei WQBian JKaushal RXu JShenkman EAKoropsak MV CLZhang YHu HZang CRothman RLXu ZfalseIdentifying environmental risk factors for post-acute sequelae of SARS-CoV-2 infection: An EHR-based cohort study from the recover program.Post-acute sequelae of SARS-CoV-2 infection (PASC) affects a wide range of organ systems among a large proportion of patients with SARS-CoV-2 infection. Although studies have identified a broad set of patient-level risk factors for PASC, little is known about the association between "exposome"-the totality of environmental exposures and the risk of PASC. Using electronic health data of patients with COVID-19 from two large clinical research networks in New York City and Florida, we identified environmental risk factors for 23 PASC symptoms and conditions from nearly 200 exposome factors. The three domains of exposome include natural environment, built environment, and social environment. We conducted a two-phase environment-wide association study. In Phase 1, we ran a mixed effects logisti2023-01-01T00:00:00Z2023 Apr2025-04-19T13:27:21.776Z2025-02-19T03:30:37.577ZS-EPMC99077883678584210.1016/j.envadv.2023.100352