{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Celona KR"],"funding":["Defense Threat Reduction Agency","National Institutes of Health","NIH HHS"],"pagination":["e0011067"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9907805"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(2)"],"pubmed_abstract":["<h4>Background</h4>Melioidosis is a disease caused by the bacterium Burkholderia pseudomallei, infecting humans and non-human primates (NHP) through contaminated soil or water. World-wide there are an estimated 165,000 human melioidosis cases each year, but recordings of NHP cases are sporadic. Clinical detection of melioidosis in humans is primarily by culturing B. pseudomallei, and there are no standardized detection protocols for NHP. NHP are an important animal model for melioidosis research including clinical trials and development of biodefense countermeasures.<h4>Methodology/principle findings</h4>We evaluated the diagnostic potential of the multiple antigen serological assay, BurkPx, in NHP using two sera sets: (i) 115 B. pseudomallei-challenged serum samples from 80 NHP collected "],"journal":["PLoS neglected tropical diseases"],"pubmed_title":["NHP BurkPx: A multiplex serodiagnostic bead assay to monitor Burkholderia pseudomallei exposures in non-human primates."],"pmcid":["PMC9907805"],"funding_grant_id":["U42 OD024282","P51 OD011104","U42 OD010568","HDTRA1-14-C-0022-NAU"],"pubmed_authors":["Sonderegger D","Hornstra H","Phillippi-Falkenstein K","Celona KR","Yi J","Sanford D","Settles EW","Keim P","Allender C","Shannon AB","Barnes MB","Monroy FP","Bohm RP","Didier ES"],"additional_accession":[]},"is_claimable":false,"name":"NHP BurkPx: A multiplex serodiagnostic bead assay to monitor Burkholderia pseudomallei exposures in non-human primates.","description":"<h4>Background</h4>Melioidosis is a disease caused by the bacterium Burkholderia pseudomallei, infecting humans and non-human primates (NHP) through contaminated soil or water. World-wide there are an estimated 165,000 human melioidosis cases each year, but recordings of NHP cases are sporadic. Clinical detection of melioidosis in humans is primarily by culturing B. pseudomallei, and there are no standardized detection protocols for NHP. NHP are an important animal model for melioidosis research including clinical trials and development of biodefense countermeasures.<h4>Methodology/principle findings</h4>We evaluated the diagnostic potential of the multiple antigen serological assay, BurkPx, in NHP using two sera sets: (i) 115 B. pseudomallei-challenged serum samples from 80 NHP collected ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-08-14T03:05:40.013Z","creation":"2025-04-04T23:52:36.854Z"},"accession":"S-EPMC9907805","cross_references":{"pubmed":["36753522"],"doi":["10.1371/journal.pntd.0011067"]}}