{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(2)"],"submitter":["Ohnishi M"],"pubmed_abstract":["In the chronic phase after intracerebral hemorrhage (ICH), the aftereffect-associated lowering of motivation burdens many patients; however, the pathogenic mechanism is unclear. Here, we revealed for the first time that indoleamine 2, 3-dioxygenase (IDO) expression and enzyme activity are increased in the collagenase-induced murine ICH model. IDO is a rate-limiting enzyme situated at the beginning of the kynurenine pathway and converts tryptophan, a source of serotonin (5-hydroxytryptamine; 5-HT), to kynurenine. In this study, we showed that IDO is localized in 5-HTergic neurons. After ICH, the synaptosomal 5-HT level decreased, but this effect was neutralized by subcutaneous injections of 1-methyl tryptophan (MT), a specific IDO inhibitor. These results suggest that ICH-induced IDO weaken"],"journal":["PloS one"],"pagination":["e0273037"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9907831"],"repository":["biostudies-literature"],"pubmed_title":["Indoleamine 2, 3-dioxygenase is responsible for low stress tolerance after intracerebral hemorrhage."],"pmcid":["PMC9907831"],"pubmed_authors":["Aokawa H","Hata T","Akagi M","Ohnishi M","Inoue A","Yonemura S","Yamashita-Ibara M","Maehara S","Yokofujita O","Kotsuki M"],"additional_accession":[]},"is_claimable":false,"name":"Indoleamine 2, 3-dioxygenase is responsible for low stress tolerance after intracerebral hemorrhage.","description":"In the chronic phase after intracerebral hemorrhage (ICH), the aftereffect-associated lowering of motivation burdens many patients; however, the pathogenic mechanism is unclear. Here, we revealed for the first time that indoleamine 2, 3-dioxygenase (IDO) expression and enzyme activity are increased in the collagenase-induced murine ICH model. IDO is a rate-limiting enzyme situated at the beginning of the kynurenine pathway and converts tryptophan, a source of serotonin (5-hydroxytryptamine; 5-HT), to kynurenine. In this study, we showed that IDO is localized in 5-HTergic neurons. After ICH, the synaptosomal 5-HT level decreased, but this effect was neutralized by subcutaneous injections of 1-methyl tryptophan (MT), a specific IDO inhibitor. These results suggest that ICH-induced IDO weaken","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T23:52:44.308Z","creation":"2025-04-04T23:52:44.308Z"},"accession":"S-EPMC9907831","cross_references":{"pubmed":["36753496"],"doi":["10.1371/journal.pone.0273037"]}}