{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wozniak E"],"funding":["Uniwersytet Medyczny w Lodzi"],"pagination":["e0280741"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9907854"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(2)"],"pubmed_abstract":["Atherosclerosis and cardiovascular events can be prevented, or treated, using statin therapy, either alone or in combination with ezetimibe. Chronic inflammation, vascular proliferation, and the development of atherosclerosis are also influenced by 25-hydroxycholesterol (25-OHC). The aim of the study was to compare the direct pleiotropic effects of two commonly-used statins (atorvastatin, rosuvastatin), ezetimibe, and their combinations, on the mRNA expression of pro-inflammatory IL1β, IL-18 and IL-23 and anti-inflammatory TGFβ, IL-35 (EBI3, IL-12 subunits), IL-10 and IL-37, in endothelial cells damaged by 25-OHC. It also analyzed IL-35 expression at the protein level. HUVECs were stimulated with atorvastatin (5 μM), rosuvastatin (10 μM), ezetimibe (1.22 μM), atorvastatin-ezetimibe (5 μM +"],"journal":["PloS one"],"pubmed_title":["The effect of lipid-lowering therapies on the pro-inflammatory and anti-inflammatory properties of vascular endothelial cells."],"pmcid":["PMC9907854"],"funding_grant_id":["503/5-165-01/503-51-001-19-00"],"pubmed_authors":["Wozniak E","Broncel M","Niedzielski M","Wozniak A","Gorzelak-Pabis P"],"additional_accession":[]},"is_claimable":false,"name":"The effect of lipid-lowering therapies on the pro-inflammatory and anti-inflammatory properties of vascular endothelial cells.","description":"Atherosclerosis and cardiovascular events can be prevented, or treated, using statin therapy, either alone or in combination with ezetimibe. Chronic inflammation, vascular proliferation, and the development of atherosclerosis are also influenced by 25-hydroxycholesterol (25-OHC). The aim of the study was to compare the direct pleiotropic effects of two commonly-used statins (atorvastatin, rosuvastatin), ezetimibe, and their combinations, on the mRNA expression of pro-inflammatory IL1β, IL-18 and IL-23 and anti-inflammatory TGFβ, IL-35 (EBI3, IL-12 subunits), IL-10 and IL-37, in endothelial cells damaged by 25-OHC. It also analyzed IL-35 expression at the protein level. HUVECs were stimulated with atorvastatin (5 μM), rosuvastatin (10 μM), ezetimibe (1.22 μM), atorvastatin-ezetimibe (5 μM +","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-18T14:23:35.757Z","creation":"2025-04-07T00:30:38.779Z"},"accession":"S-EPMC9907854","cross_references":{"pubmed":["36753488"],"doi":["10.1371/journal.pone.0280741"]}}