{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hassan A"],"funding":["NCATS NIH HHS","NIAID NIH HHS","NIMH NIH HHS","California HIV/AIDS Research Program"],"pagination":["529-535"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9908082"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(7)"],"pubmed_abstract":["HIV pre-exposure prophylaxis (PrEP) has been associated with incident hepatitis C virus (HCV) infection in men who have sex with men (MSM) due to decreased condom use. We examined rates of HCV among MSM and transgender women at high-risk of HIV on PrEP in Southern California using data from two trials (NCT01761643 and NCT01781806). Five of 599 participants (0.84%, 95% CI, 0.27-1.93) had HCV antibodies detected at entry. Factors associated with HCV seropositivity included being older (p = .002) and lower education level (p < .001). HCV-positive participants had no reported cases of sexually transmitted infection (rectal, urethral or pharyngeal gonorrhoea and/or chlamydia) at entry while HCV-negative participants had a prevalence of 18% (95% CI, 15%-21%). There were no significant differences in substance use and sexual risk behaviour between HCV-positive and HCV-negative participants 1-3 months prior to entry. Among early PrEP adopters, incident HCV did not occur despite ongoing condomless intercourse. Screening intervals for HCV in MSM on PrEP should be led by a risk behaviour assessment."],"journal":["Journal of viral hepatitis"],"pubmed_title":["Low incidence and prevalence of hepatitis C in two cohorts of HIV pre-exposure prophylaxis adherence interventions in men who have sex with men in Southern California."],"pmcid":["PMC9908082"],"funding_grant_id":["P30 AI028697","UL1 TR000124","UL1 TR001881","P30 MH058107"],"pubmed_authors":["Agustin HGS","Morris SR","Corado K","Landovitz RJ","Kofron R","Hassan A","Bolan R","Dube MP","Burke L"],"additional_accession":[]},"is_claimable":false,"name":"Low incidence and prevalence of hepatitis C in two cohorts of HIV pre-exposure prophylaxis adherence interventions in men who have sex with men in Southern California.","description":"HIV pre-exposure prophylaxis (PrEP) has been associated with incident hepatitis C virus (HCV) infection in men who have sex with men (MSM) due to decreased condom use. We examined rates of HCV among MSM and transgender women at high-risk of HIV on PrEP in Southern California using data from two trials (NCT01761643 and NCT01781806). Five of 599 participants (0.84%, 95% CI, 0.27-1.93) had HCV antibodies detected at entry. Factors associated with HCV seropositivity included being older (p = .002) and lower education level (p < .001). HCV-positive participants had no reported cases of sexually transmitted infection (rectal, urethral or pharyngeal gonorrhoea and/or chlamydia) at entry while HCV-negative participants had a prevalence of 18% (95% CI, 15%-21%). There were no significant differences in substance use and sexual risk behaviour between HCV-positive and HCV-negative participants 1-3 months prior to entry. Among early PrEP adopters, incident HCV did not occur despite ongoing condomless intercourse. Screening intervals for HCV in MSM on PrEP should be led by a risk behaviour assessment.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-05-29T06:09:41.767Z","creation":"2024-10-18T23:14:52.369Z"},"accession":"S-EPMC9908082","cross_references":{"pubmed":["35357767"],"doi":["10.1111/jvh.13678"]}}