{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Peng G"],"pubmed_abstract":["Increasing evidence reveals that the interaction between tumor cells and tumor-associated macrophages (TAMs) facilitates the progression of prostate cancer, but the related mechanisms remained unclear. This study determined how gankyrin, a component of the 19S regulatory complex of the 26S proteasome, regulates the progression and androgen deprivation therapy (ADT) resistance of prostate cancer through tumor cell-TAM interactions. <i>In vitro</i> functional experiments and <i>in vivo</i> subcutaneous tumor models were used to explore the biological role and molecular mechanisms of gankyrin in prostate cancer cell-TAM interactions. 234 prostate cancer patients were randomly divided into training and validation cohorts to examine the prognostic value of gankyrin through immunohistochemistry "],"journal":["Oncoimmunology"],"pagination":["2173422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9908295"],"repository":["biostudies-literature"],"pubmed_title":["Gankyrin-mediated interaction between cancer cells and tumor-associated macrophages facilitates prostate cancer progression and androgen deprivation therapy resistance."],"pmcid":["PMC9908295"],"pubmed_authors":["Jiang Y","Gan S","Peng G","Wang C","Dong K","Qu M","Wang H","Gao X","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Gankyrin-mediated interaction between cancer cells and tumor-associated macrophages facilitates prostate cancer progression and androgen deprivation therapy resistance.","description":"Increasing evidence reveals that the interaction between tumor cells and tumor-associated macrophages (TAMs) facilitates the progression of prostate cancer, but the related mechanisms remained unclear. This study determined how gankyrin, a component of the 19S regulatory complex of the 26S proteasome, regulates the progression and androgen deprivation therapy (ADT) resistance of prostate cancer through tumor cell-TAM interactions. <i>In vitro</i> functional experiments and <i>in vivo</i> subcutaneous tumor models were used to explore the biological role and molecular mechanisms of gankyrin in prostate cancer cell-TAM interactions. 234 prostate cancer patients were randomly divided into training and validation cohorts to examine the prognostic value of gankyrin through immunohistochemistry ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-19T04:44:25.162Z","creation":"2025-04-19T04:44:25.162Z"},"accession":"S-EPMC9908295","cross_references":{"pubmed":["36776524"],"doi":["10.1080/2162402X.2023.2173422"]}}