{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li QS"],"funding":["NCATS NIH HHS","NIMH NIH HHS","NCI NIH HHS","The study was supported by Janssen Research &amp; Development, LLC"],"pagination":["891-900"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9908547"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(2)"],"pubmed_abstract":["Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated with suicide death and suicidal behavior. Meta-analysis for suicide death was performed using 3765 cases from Utah and matching 6572 controls of European ancestry. Meta-analysis for suicidal behavior using data across five cohorts (n = 8315 cases and 256,478 psychiatric or populational controls of European ancestry) was also performed. One locus in neuroligin 1 (NLGN1) passing the genome-wide significance threshold for suicide death was identified (top SNP rs73182688, with p = 5.48 × 10<sup>-8</sup> before and p = 4.55 × 10<sup>-8</sup> after mtCOJO analysis conditioning on MDD to remove genetic effects on suicide mediated by MDD). Conditioning on suicidal attempts did not significantly change the a"],"journal":["Molecular psychiatry"],"pubmed_title":["Genome-wide association study meta-analysis of suicide death and suicidal behavior."],"pmcid":["PMC9908547"],"funding_grant_id":["P30 CA042014","R01 MH123619","K01 MH093731","R01 MH099134","R01 MH123489","UL1 TR002538"],"pubmed_authors":["FinnGen, International Suicide Genetics Consortium","DiBlasi E","Shabalin AA","Drevets WC","Coon H","Li QS","Gopal S","Canuso CM","Palotie A","Docherty AR"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide association study meta-analysis of suicide death and suicidal behavior.","description":"Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated with suicide death and suicidal behavior. Meta-analysis for suicide death was performed using 3765 cases from Utah and matching 6572 controls of European ancestry. Meta-analysis for suicidal behavior using data across five cohorts (n = 8315 cases and 256,478 psychiatric or populational controls of European ancestry) was also performed. One locus in neuroligin 1 (NLGN1) passing the genome-wide significance threshold for suicide death was identified (top SNP rs73182688, with p = 5.48 × 10<sup>-8</sup> before and p = 4.55 × 10<sup>-8</sup> after mtCOJO analysis conditioning on MDD to remove genetic effects on suicide mediated by MDD). Conditioning on suicidal attempts did not significantly change the a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-07-14T20:07:19.387Z","creation":"2025-04-19T02:45:19.102Z"},"accession":"S-EPMC9908547","cross_references":{"pubmed":["36253440"],"doi":["10.1038/s41380-022-01828-9"]}}