biostudies-literatureLi QSNCATS NIH HHSNIMH NIH HHSNCI NIH HHSThe study was supported by Janssen Research & Development, LLC891-900https://www.ebi.ac.uk/biostudies/studies/S-EPMC9908547biostudies-literatureUnknown28(2)Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated with suicide death and suicidal behavior. Meta-analysis for suicide death was performed using 3765 cases from Utah and matching 6572 controls of European ancestry. Meta-analysis for suicidal behavior using data across five cohorts (n = 8315 cases and 256,478 psychiatric or populational controls of European ancestry) was also performed. One locus in neuroligin 1 (NLGN1) passing the genome-wide significance threshold for suicide death was identified (top SNP rs73182688, with p = 5.48 × 10^-8 before and p = 4.55 × 10^-8 after mtCOJO analysis conditioning on MDD to remove genetic effects on suicide mediated by MDD). Conditioning on suicidal attempts did not significantly change the aMolecular psychiatryGenome-wide association study meta-analysis of suicide death and suicidal behavior.PMC9908547P30 CA042014R01 MH123619K01 MH093731R01 MH099134R01 MH123489UL1 TR002538FinnGen, International Suicide Genetics ConsortiumDiBlasi EShabalin AADrevets WCCoon HLi QSGopal SCanuso CMPalotie ADocherty ARfalseGenome-wide association study meta-analysis of suicide death and suicidal behavior.Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated with suicide death and suicidal behavior. Meta-analysis for suicide death was performed using 3765 cases from Utah and matching 6572 controls of European ancestry. Meta-analysis for suicidal behavior using data across five cohorts (n = 8315 cases and 256,478 psychiatric or populational controls of European ancestry) was also performed. One locus in neuroligin 1 (NLGN1) passing the genome-wide significance threshold for suicide death was identified (top SNP rs73182688, with p = 5.48 × 10^-8 before and p = 4.55 × 10^-8 after mtCOJO analysis conditioning on MDD to remove genetic effects on suicide mediated by MDD). Conditioning on suicidal attempts did not significantly change the a2023-01-01T00:00:00Z2023 Feb2026-07-14T20:07:19.387Z2025-04-19T02:45:19.102ZS-EPMC99085473625344010.1038/s41380-022-01828-9