biostudies-literatureUnknown137(3)Han YAnemia of inflammation (AI) is associated with inflammatory diseases, and inflammation-induced iron metabolism disorder is the major pathogenic factor. Earlier studies have reported a tendency of AI in periodontitis patients, but the explicit relationship and possible pathological mechanisms remain unclear. Here, the analyses of both periodontitis patients and a mouse model of ligature-induced experimental periodontitis showed that periodontitis was associated with lower levels of hemoglobin and hematocrit with evidence of systemic inflammation (increased white blood cell levels) and evidence of iron restriction (low serum iron along with a high serum hepcidin and ferritin levels), in accordance with the current diagnosis criteria for AI. Moreover, periodontal therapy improved the anemia sClinical science (London, England : 1979)251-264https://www.ebi.ac.uk/biostudies/studies/S-EPMC9908573biostudies-literatureThe tendency of anemia of inflammation in periodontal diseases.PMC9908573Miao LLXv MHou JLuo ZHan YYue ZGChang SZhan YfalseThe tendency of anemia of inflammation in periodontal diseases.Anemia of inflammation (AI) is associated with inflammatory diseases, and inflammation-induced iron metabolism disorder is the major pathogenic factor. Earlier studies have reported a tendency of AI in periodontitis patients, but the explicit relationship and possible pathological mechanisms remain unclear. Here, the analyses of both periodontitis patients and a mouse model of ligature-induced experimental periodontitis showed that periodontitis was associated with lower levels of hemoglobin and hematocrit with evidence of systemic inflammation (increased white blood cell levels) and evidence of iron restriction (low serum iron along with a high serum hepcidin and ferritin levels), in accordance with the current diagnosis criteria for AI. Moreover, periodontal therapy improved the anemia s2023-01-01T00:00:00Z2023 Feb2026-03-17T15:26:21.542Z2025-04-06T18:40:30.887ZS-EPMC99085733670542710.1042/CS20220524