biostudies-literatureUnknown14(1)Islam MTRemarkable advances in single cell genomics have presented unique challenges and opportunities for interrogating a wealth of biomedical inquiries. High dimensional genomic data are inherently complex because of intertwined relationships among the genes. Existing methods, including emerging deep learning-based approaches, do not consider the underlying biological characteristics during data processing, which greatly compromises the performance of data analysis and hinders the maximal utilization of state-of-the-art genomic techniques. In this work, we develop an entropy-based cartography strategy to contrive the high dimensional gene expression data into a configured image format, referred to as genomap, with explicit integration of the genomic interactions. This unique cartography casts thNature communications679https://www.ebi.ac.uk/biostudies/studies/S-EPMC9908983biostudies-literatureCartography of Genomic Interactions Enables Deep Analysis of Single-Cell Expression Data.PMC9908983Xing LIslam MTfalseCartography of Genomic Interactions Enables Deep Analysis of Single-Cell Expression Data.Remarkable advances in single cell genomics have presented unique challenges and opportunities for interrogating a wealth of biomedical inquiries. High dimensional genomic data are inherently complex because of intertwined relationships among the genes. Existing methods, including emerging deep learning-based approaches, do not consider the underlying biological characteristics during data processing, which greatly compromises the performance of data analysis and hinders the maximal utilization of state-of-the-art genomic techniques. In this work, we develop an entropy-based cartography strategy to contrive the high dimensional gene expression data into a configured image format, referred to as genomap, with explicit integration of the genomic interactions. This unique cartography casts th2023-01-01T00:00:00Z2023 Feb2026-03-18T13:46:39.069Z2025-04-04T18:43:37.178ZS-EPMC99089833675504710.1038/s41467-023-36383-6