{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Morsli M"],"pubmed_abstract":["In southern France, cases of community-acquired meningitis syndrome (CAM) are typically clustered as outbreaks with determinants which remain unknown. This 61-month retrospective investigation in Nîmes and Marseille university hospital laboratories, yielded 2,209/20,779 (10.63%) documented CAM cases caused by 62 different micro-organisms, represented by seasonal viral etiologies (78.8%), including Enterovirus, <i>Herpes Simplex Virus</i> (HSV), and <i>Varicella-Zoster Virus</i> (VZV; 1,620/2,209 = 73.4%). Multi correspondence analysis revealed an association of infection with age and sex, with the risk of infection being relatively higher in young men, as confirmed by Fisher's exact test (<i>p</i> < 10<sup>-3</sup>). Bacterial meningitis accounted for 20% of cases, mostly caused by <i>Streptococcus pneumoniae</i> (27.4% of cases), <i>Neisseria meningitidis</i> (12.5%), and <i>Haemophilus influenzae</i> (9.5%) with bacteria/virus coinfection (0.9%), and only six cases of documented fungal meningitis. In total, 62.6% of cases, of which 88.7% were undocumented, arose from 10 outbreaks. 33.2% of undocumented cases were aged >60 years compared to 19.2% of documented cases (<i>p</i> < 0.001), and viral infection was more common in the summer (87.5%) compared to other seasons (72.3%; <i>p</i> < 0.001). Outbreaks most often started in Nîmes and moved eastward toward Marseille at a speed of ~9 km/day, and these dynamics significantly correlated with atmospheric temperature, especially during summer outbreaks. In particular, the incidence of Enterovirus-driven outbreaks correlated with temperature, revealing correlation coefficients of 0.64 in Nîmes and 0.72 in Marseille, and its occurrence in Marseille lagged that in Nîmes by 1-2 weeks. Tracing the dynamics of CAM outbreak during this retrospective investigation in southern France yielded a speed of displacement that correlated with the variation in temperature between both cities, and these results provide clues for the next occurrence of undocumented outbreaks."],"journal":["Frontiers in microbiology"],"pagination":["1102130"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9909019"],"repository":["biostudies-literature"],"pubmed_title":["Dynamics of community-acquired meningitis syndrome outbreaks in southern France."],"pmcid":["PMC9909019"],"pubmed_authors":["Morsli M","Salipante F","Drancourt M","Kerharo Q","Dunyach-Remy C","Lavigne JP","Boudet A","Stephan R","Zandotti C"],"additional_accession":[]},"is_claimable":false,"name":"Dynamics of community-acquired meningitis syndrome outbreaks in southern France.","description":"In southern France, cases of community-acquired meningitis syndrome (CAM) are typically clustered as outbreaks with determinants which remain unknown. This 61-month retrospective investigation in Nîmes and Marseille university hospital laboratories, yielded 2,209/20,779 (10.63%) documented CAM cases caused by 62 different micro-organisms, represented by seasonal viral etiologies (78.8%), including Enterovirus, <i>Herpes Simplex Virus</i> (HSV), and <i>Varicella-Zoster Virus</i> (VZV; 1,620/2,209 = 73.4%). Multi correspondence analysis revealed an association of infection with age and sex, with the risk of infection being relatively higher in young men, as confirmed by Fisher's exact test (<i>p</i> < 10<sup>-3</sup>). Bacterial meningitis accounted for 20% of cases, mostly caused by <i>Streptococcus pneumoniae</i> (27.4% of cases), <i>Neisseria meningitidis</i> (12.5%), and <i>Haemophilus influenzae</i> (9.5%) with bacteria/virus coinfection (0.9%), and only six cases of documented fungal meningitis. In total, 62.6% of cases, of which 88.7% were undocumented, arose from 10 outbreaks. 33.2% of undocumented cases were aged >60 years compared to 19.2% of documented cases (<i>p</i> < 0.001), and viral infection was more common in the summer (87.5%) compared to other seasons (72.3%; <i>p</i> < 0.001). Outbreaks most often started in Nîmes and moved eastward toward Marseille at a speed of ~9 km/day, and these dynamics significantly correlated with atmospheric temperature, especially during summer outbreaks. In particular, the incidence of Enterovirus-driven outbreaks correlated with temperature, revealing correlation coefficients of 0.64 in Nîmes and 0.72 in Marseille, and its occurrence in Marseille lagged that in Nîmes by 1-2 weeks. Tracing the dynamics of CAM outbreak during this retrospective investigation in southern France yielded a speed of displacement that correlated with the variation in temperature between both cities, and these results provide clues for the next occurrence of undocumented outbreaks.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T23:57:11.501Z","creation":"2025-04-04T23:57:11.501Z"},"accession":"S-EPMC9909019","cross_references":{"pubmed":["36777029"],"doi":["10.3389/fmicb.2022.1102130"]}}