{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Daniel N"],"funding":["Quebec Cardiometabolic Health, Diabetes and Obesity","Canadian Institutes of Health Research","CIHR"],"pagination":["zqac069"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9909367"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(2)"],"pubmed_abstract":["We compared endogenous ω-3 PUFA production to supplementation for improving obesity-related metabolic dysfunction. Fat-1 transgenic mice, who endogenously convert exogenous ω-6 to ω-3 PUFA, and wild-type littermates were fed a high-fat diet and a daily dose of either ω-3 or ω-6 PUFA-rich oil for 12 wk. The endogenous ω-3 PUFA production improved glucose intolerance and insulin resistance but not hepatic steatosis. Conversely, ω-3 PUFA supplementation fully prevented hepatic steatosis but failed to improve insulin resistance. Both models increased hepatic levels of ω-3 PUFA-containing 2-monoacylglycerol and N-acylethanolamine congeners, and reduced levels of ω-6 PUFA-derived endocannabinoids with ω-3 PUFA supplementation being more efficacious. Reduced hepatic lipid accumulation associated "],"journal":["Function (Oxford, England)"],"pubmed_title":["Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders."],"pmcid":["PMC9909367"],"funding_grant_id":["FDN-746 143247"],"pubmed_authors":["Le Barz M","Garofalo C","Jobin C","Julien IB","Gauthier J","Kang JX","Chassaing B","Farabos D","Flamand N","Mitchell PL","Di Marzo V","Varin TV","Daniel N","Levy E","Lamaziere A","Roy D","Raymond F","Barbier O","Silvestri C","Pilon G","Trottier J","Marette A"],"additional_accession":[]},"is_claimable":false,"name":"Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders.","description":"We compared endogenous ω-3 PUFA production to supplementation for improving obesity-related metabolic dysfunction. Fat-1 transgenic mice, who endogenously convert exogenous ω-6 to ω-3 PUFA, and wild-type littermates were fed a high-fat diet and a daily dose of either ω-3 or ω-6 PUFA-rich oil for 12 wk. The endogenous ω-3 PUFA production improved glucose intolerance and insulin resistance but not hepatic steatosis. Conversely, ω-3 PUFA supplementation fully prevented hepatic steatosis but failed to improve insulin resistance. Both models increased hepatic levels of ω-3 PUFA-containing 2-monoacylglycerol and N-acylethanolamine congeners, and reduced levels of ω-6 PUFA-derived endocannabinoids with ω-3 PUFA supplementation being more efficacious. Reduced hepatic lipid accumulation associated ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T20:17:47.946Z","creation":"2025-02-19T03:30:42.692Z"},"accession":"S-EPMC9909367","cross_references":{"pubmed":["36778746"],"doi":["10.1093/function/zqac069"]}}