{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Reinhold D"],"funding":["Charité - Universitätsmedizin Berlin"],"pubmed_abstract":["Patients with COVID-19 can have a variety of neurological symptoms, but the active involvement of central nervous system (CNS) in COVID-19 remains unclear. While routine cerebrospinal fluid (CSF) analyses in patients with neurological manifestations of COVID-19 generally show no or only mild inflammation, more detailed data on inflammatory mediators in the CSF of patients with COVID-19 are scarce. We studied the inflammatory response in paired CSF and serum samples of patients with COVID-19 (n = 38). Patients with herpes simplex virus encephalitis (HSVE, n = 10) and patients with non-inflammatory, non-neurodegenerative neurological diseases (n = 28) served as controls. We used proteomics, enzyme-linked immunoassays, and semiquantitative cytokine arrays to characterize inflammatory proteins"],"journal":["Journal of neuroinflammation"],"pagination":["30"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9909638"],"repository":["biostudies-literature"],"pubmed_title":["The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation."],"pmcid":["PMC9909638"],"pubmed_authors":["Duzel E","Kjems J","Sadlowski H","Otto C","Stubbemann P","Jarius S","Mulleder M","Endres M","Reinhold D","Streit S","Teegen B","Perschel FH","Kortvelyessy P","Stocker W","Kurth F","Ralser M","Farztdinov V","Kuhn J","Heppner F","Radbruch H","Yan Y","Meisel C","Ruprecht K","Guttek K","Goihl A","Vielhaber S","Veno M","Sander LE"],"additional_accession":[]},"is_claimable":false,"name":"The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation.","description":"Patients with COVID-19 can have a variety of neurological symptoms, but the active involvement of central nervous system (CNS) in COVID-19 remains unclear. While routine cerebrospinal fluid (CSF) analyses in patients with neurological manifestations of COVID-19 generally show no or only mild inflammation, more detailed data on inflammatory mediators in the CSF of patients with COVID-19 are scarce. We studied the inflammatory response in paired CSF and serum samples of patients with COVID-19 (n = 38). Patients with herpes simplex virus encephalitis (HSVE, n = 10) and patients with non-inflammatory, non-neurodegenerative neurological diseases (n = 28) served as controls. We used proteomics, enzyme-linked immunoassays, and semiquantitative cytokine arrays to characterize inflammatory proteins","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-03-17T15:27:39.103Z","creation":"2024-10-18T03:18:54.442Z"},"accession":"S-EPMC9909638","cross_references":{"pubmed":["36759861"],"doi":["10.1186/s12974-023-02711-2"]}}