biostudies-literatureUnknown20(1)Reinhold DCharité - Universitätsmedizin BerlinPatients with COVID-19 can have a variety of neurological symptoms, but the active involvement of central nervous system (CNS) in COVID-19 remains unclear. While routine cerebrospinal fluid (CSF) analyses in patients with neurological manifestations of COVID-19 generally show no or only mild inflammation, more detailed data on inflammatory mediators in the CSF of patients with COVID-19 are scarce. We studied the inflammatory response in paired CSF and serum samples of patients with COVID-19 (n = 38). Patients with herpes simplex virus encephalitis (HSVE, n = 10) and patients with non-inflammatory, non-neurodegenerative neurological diseases (n = 28) served as controls. We used proteomics, enzyme-linked immunoassays, and semiquantitative cytokine arrays to characterize inflammatory proteinsJournal of neuroinflammation30https://www.ebi.ac.uk/biostudies/studies/S-EPMC9909638biostudies-literatureThe brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation.PMC9909638Duzel EKjems JSadlowski HOtto CStubbemann PJarius SMulleder MEndres MReinhold DStreit STeegen BPerschel FHKortvelyessy PStocker WKurth FRalser MFarztdinov VKuhn JHeppner FRadbruch HYan YMeisel CRuprecht KGuttek KGoihl AVielhaber SVeno MSander LEfalseThe brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation.Patients with COVID-19 can have a variety of neurological symptoms, but the active involvement of central nervous system (CNS) in COVID-19 remains unclear. While routine cerebrospinal fluid (CSF) analyses in patients with neurological manifestations of COVID-19 generally show no or only mild inflammation, more detailed data on inflammatory mediators in the CSF of patients with COVID-19 are scarce. We studied the inflammatory response in paired CSF and serum samples of patients with COVID-19 (n = 38). Patients with herpes simplex virus encephalitis (HSVE, n = 10) and patients with non-inflammatory, non-neurodegenerative neurological diseases (n = 28) served as controls. We used proteomics, enzyme-linked immunoassays, and semiquantitative cytokine arrays to characterize inflammatory proteins2023-01-01T00:00:00Z2023 Feb2026-03-17T15:27:39.103Z2024-10-18T03:18:54.442ZS-EPMC99096383675986110.1186/s12974-023-02711-2