{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["59(13)"],"submitter":["Ashman N"],"funding":["Medical Research Council","Biotechnology and Biological Sciences Research Council","Engineering and Physical Sciences Research Council"],"pubmed_abstract":["Antibody-drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity <i>in vitro</i>."],"journal":["Chemical communications (Cambridge, England)"],"pagination":["1841-1844"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9910056"],"repository":["biostudies-literature"],"pubmed_title":["Peroxide-cleavable linkers for antibody-drug conjugates."],"pmcid":["PMC9910056"],"pubmed_authors":["Walsh SJ","Greenwood RD","Tiberghien A","Spring DR","Carroll JS","Bargh JD","Ashman N"],"additional_accession":[]},"is_claimable":false,"name":"Peroxide-cleavable linkers for antibody-drug conjugates.","description":"Antibody-drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity <i>in vitro</i>.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T18:43:30.728Z","creation":"2025-04-04T18:43:30.728Z"},"accession":"S-EPMC9910056","cross_references":{"pubmed":["36722863"],"doi":["10.1039/d2cc06677g"]}}