biostudies-literatureUnknown59(13)Ashman NMedical Research CouncilBiotechnology and Biological Sciences Research CouncilEngineering and Physical Sciences Research CouncilAntibody-drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity <i>in vitro</i>.Chemical communications (Cambridge, England)1841-1844https://www.ebi.ac.uk/biostudies/studies/S-EPMC9910056biostudies-literaturePeroxide-cleavable linkers for antibody-drug conjugates.PMC9910056Walsh SJGreenwood RDTiberghien ASpring DRCarroll JSBargh JDAshman NfalsePeroxide-cleavable linkers for antibody-drug conjugates.Antibody-drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity <i>in vitro</i>.2023-01-01T00:00:00Z2023 Feb2025-04-04T18:43:30.728Z2025-04-04T18:43:30.728ZS-EPMC99100563672286310.1039/d2cc06677g