biostudies-literatureZeng XGuangdong Medical Science and Technology Research Fund ProjectProgram Natural Science Foundation of Guangdong Province, ChinaNational Key Research and Development Program of China364-371https://www.ebi.ac.uk/biostudies/studies/S-EPMC9910143biostudies-literatureUnknown25(3)<h4>Introduction</h4>To systematically review the association between smoking behavior and obstructive sleep apnea (OSA).<h4>Aims and methods</h4>PubMed, Medline, the Cochrane Library, EMBASE, and Scopus databases were used to conduct this review. The two researchers independently screened the literatures, conducted the quality assessment, and data extraction according to the inclusion and exclusion criteria. The RevMan 5.3 was used to analysis the apnea hypopnea index (AHI) index, min saturation of oxyhemoglobin (SaO2), Epworth Sleepiness Scale (ESS) score, and oxygen desaturation index (DOI) and publication bias analysis to assess the effect of smoking on OSA patients. Furthermore, we performed subgroup of the severity of OSA, different countries of sample origin (western countries or eaNicotine & tobacco research : official journal of the Society for Research on Nicotine and TobaccoAssociation Between Smoking Behavior and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.PMC99101432019A1515010981B20191032018YFC13136002016YFC0901102Wu KRen YWang DZhang NZeng XLuo YYang QZhang SfalseAssociation Between Smoking Behavior and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.<h4>Introduction</h4>To systematically review the association between smoking behavior and obstructive sleep apnea (OSA).<h4>Aims and methods</h4>PubMed, Medline, the Cochrane Library, EMBASE, and Scopus databases were used to conduct this review. The two researchers independently screened the literatures, conducted the quality assessment, and data extraction according to the inclusion and exclusion criteria. The RevMan 5.3 was used to analysis the apnea hypopnea index (AHI) index, min saturation of oxyhemoglobin (SaO2), Epworth Sleepiness Scale (ESS) score, and oxygen desaturation index (DOI) and publication bias analysis to assess the effect of smoking on OSA patients. Furthermore, we performed subgroup of the severity of OSA, different countries of sample origin (western countries or ea2023-01-01T00:00:00Z2023 Feb2025-04-04T18:43:28.715Z2025-04-04T18:43:28.715ZS-EPMC99101433592238810.1093/ntr/ntac126