biostudies-literatureMarinho-Junior JFCNPqFACEPECAPESe0010996https://www.ebi.ac.uk/biostudies/studies/S-EPMC9910795biostudies-literatureUnknown17(1)<h4>Background</h4>The epidemiological significance of wildlife infections with aetiological agents causing human infectious diseases is largely determined by their infection status, contact potential with humans (via vectors for vector-borne diseases), and their infectiousness to maintain onward transmission. This study quantified these parameters in wild and synanthropic naturally infected rodent populations in an endemic region of tegumentary leishmaniasis in northeast Brazil.<h4>Methods</h4>Capture-mark-recapture (CMR) of rodents was conducted over 27 months in domestic/peri domestic environs, household plantations and nearby Atlantic Forest (9,920 single trap nights). Rodent clinical samples (blood and ear tissue) were tested for infection by conventional PCR and quantitative PCR (qPCPLoS neglected tropical diseasesHigh levels of infectiousness of asymptomatic Leishmania (Viannia) braziliensis infections in wild rodents highlights their importance in the epidemiology of American Tegumentary Leishmaniasis in Brazil.PMC9910795400331/2012-80024.4.00/1323038.005276/2011-3Marinho-Junior JFde Paiva Cavalcanti MMonteiro JFCLSSales de Carvalho AWShaw JCourtenay Ode Carvalho FGBrandao-Filho SPfalseHigh levels of infectiousness of asymptomatic Leishmania (Viannia) braziliensis infections in wild rodents highlights their importance in the epidemiology of American Tegumentary Leishmaniasis in Brazil.<h4>Background</h4>The epidemiological significance of wildlife infections with aetiological agents causing human infectious diseases is largely determined by their infection status, contact potential with humans (via vectors for vector-borne diseases), and their infectiousness to maintain onward transmission. This study quantified these parameters in wild and synanthropic naturally infected rodent populations in an endemic region of tegumentary leishmaniasis in northeast Brazil.<h4>Methods</h4>Capture-mark-recapture (CMR) of rodents was conducted over 27 months in domestic/peri domestic environs, household plantations and nearby Atlantic Forest (9,920 single trap nights). Rodent clinical samples (blood and ear tissue) were tested for infection by conventional PCR and quantitative PCR (qPC2023-01-01T00:00:00Z2023 Jan2025-04-04T18:43:24.439Z2025-04-04T18:43:24.439ZS-EPMC99107953671634510.1371/journal.pntd.0010996