{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Funsten MC"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","NIGMS NIH HHS","NIH HHS"],"pagination":["213-227.e9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9911364"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(2)"],"pubmed_abstract":["Diet and commensals can affect the development of autoimmune diseases like type 1 diabetes (T1D). However, whether dietary interventions are microbe-mediated was unclear. We found that a diet based on hydrolyzed casein (HC) as a protein source protects non-obese diabetic (NOD) mice in conventional and germ-free (GF) conditions via improvement in the physiology of insulin-producing cells to reduce autoimmune activation. The addition of gluten (a cereal protein complex associated with celiac disease) facilitates autoimmunity dependent on microbial proteolysis of gluten: T1D develops in GF animals monocolonized with Enterococcus faecalis harboring secreted gluten-digesting proteases but not in mice colonized with protease deficient bacteria. Gluten digestion by E. faecalis generates T cell-ac"],"journal":["Cell host & microbe"],"pubmed_title":["Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes."],"pmcid":["PMC9911364"],"funding_grant_id":["U54 OD020351","T32 GM007183","R01 AI158744","R01 DK046266","R29 DK046266","R21 AI115683","R01 AI082418","R01 DK095735","T32 AI007090","P30 DK042086"],"pubmed_authors":["Ratiu J","Khan AA","Lee J","Dahal-Koirala S","Yurkovetskiy LA","Chervonsky AV","Funsten MC","Senter KI","Kuznetsov A","Hansen CHF","Antonopoulos DA","Reiman D","Dunny GM","Sollid LM","Serreze D"],"additional_accession":[]},"is_claimable":false,"name":"Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes.","description":"Diet and commensals can affect the development of autoimmune diseases like type 1 diabetes (T1D). However, whether dietary interventions are microbe-mediated was unclear. We found that a diet based on hydrolyzed casein (HC) as a protein source protects non-obese diabetic (NOD) mice in conventional and germ-free (GF) conditions via improvement in the physiology of insulin-producing cells to reduce autoimmune activation. The addition of gluten (a cereal protein complex associated with celiac disease) facilitates autoimmunity dependent on microbial proteolysis of gluten: T1D develops in GF animals monocolonized with Enterococcus faecalis harboring secreted gluten-digesting proteases but not in mice colonized with protease deficient bacteria. Gluten digestion by E. faecalis generates T cell-ac","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-28T21:49:44.678Z","creation":"2025-04-03T23:49:46.653Z"},"accession":"S-EPMC9911364","cross_references":{"pubmed":["36603588"],"doi":["10.1016/j.chom.2022.12.009"]}}