{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Lowe JR"],"funding":["NIDA NIH HHS","NIAAA NIH HHS"],"pubmed_abstract":["<h4>Background</h4>With significant increases in opioid use/misuse and persistent high prevalence of prenatal alcohol exposure (PAE), identifying infants at risk for long-term developmental sequelae due to these exposures remains an urgent need. This study reports on developmental outcomes in young children from a prospective cohort, ENRICH-1, which recruited pregnant women and followed up maternal-infant pairs.<h4>Methods</h4>Subjects were assigned to four study groups based on prenatal use of medications for opioid use disorder (MOUD), PAE, MOUD+PAE, and unexposed controls (UC). Mixed effects modeling was used to evaluate changes in the Bayley Scales of Infant Development-III (BSID-III) Cognitive, Language, and Motor scores between 6 and 20 months.<h4>Results</h4>There was a significant "],"journal":["Pediatric research"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9911560"],"repository":["biostudies-literature"],"pubmed_title":["Early developmental trajectory of children with prenatal alcohol and opioid exposure."],"pmcid":["PMC9911560"],"funding_grant_id":["R01 AA021771","R34 DA050237"],"pubmed_authors":["Roberts MH","Stephen JM","DiDomenico J","Rodriguez DE","Lowe JR","Bakhireva LN"],"additional_accession":[]},"is_claimable":false,"name":"Early developmental trajectory of children with prenatal alcohol and opioid exposure.","description":"<h4>Background</h4>With significant increases in opioid use/misuse and persistent high prevalence of prenatal alcohol exposure (PAE), identifying infants at risk for long-term developmental sequelae due to these exposures remains an urgent need. This study reports on developmental outcomes in young children from a prospective cohort, ENRICH-1, which recruited pregnant women and followed up maternal-infant pairs.<h4>Methods</h4>Subjects were assigned to four study groups based on prenatal use of medications for opioid use disorder (MOUD), PAE, MOUD+PAE, and unexposed controls (UC). Mixed effects modeling was used to evaluate changes in the Bayley Scales of Infant Development-III (BSID-III) Cognitive, Language, and Motor scores between 6 and 20 months.<h4>Results</h4>There was a significant ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-19T22:26:01.075Z","creation":"2025-04-19T22:26:01.075Z"},"accession":"S-EPMC9911560","cross_references":{"pubmed":["35948606"],"doi":["10.1038/s41390-022-02252-z"]}}