{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rescigno M"],"funding":["Ministero della Salute"],"pagination":["1104124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9911671"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14"],"pubmed_abstract":["<h4>Introduction</h4>Immunocompromised patients have been shown to have an impaired immune response to COVID-19 vaccines.<h4>Methods</h4>Here we compared the B-cell, T-cell and neutralizing antibody response to WT and Omicron BA.2 SARS-CoV-2 virus after the fourth dose of mRNA COVID-19 vaccines in patients with hematological malignancies (HM, n=71), solid tumors (ST, n=39) and immune-rheumatological (IR, n=25) diseases. The humoral and T-cell responses to SARS-CoV-2 vaccination were analyzed by quantifying the anti-RBD antibodies, their neutralization activity and the IFN-γ released after spike specific stimulation.<h4>Results</h4>We show that the T-cell response is similarly boosted by the fourth dose across the different subgroups, while the antibody response is improved only in patients"],"journal":["Frontiers in immunology"],"pubmed_title":["Neutralizing antibodies to Omicron after the fourth SARS-CoV-2 mRNA vaccine dose in immunocompromised patients highlight the need of additional boosters."],"pmcid":["PMC9911671"],"funding_grant_id":["Ricerca Corrente 2021-Special Projects-VAX4FRAIL"],"pubmed_authors":["Pozzi C","Salvarani C","Dagna L","Trinca S","Barberini A","Motta F","Filippi M","Turola E","Nitti R","Pantaleo MA","Marchesi F","Merli F","Casetti R","Girardi E","Catanoso MG","Ciceri F","Stefoni V","Rubino M","Divella R","Francalancia M","Garrisi V","Leone S","Ciliberto G","Fondazione RM","Matusali G","Conti L","Agrati C","Castilletti C","Fornasa G","Frangiamore SBR","Di Cosimo S","Miggiano C","Laroni A","Azzolini E","Germagnoli L","Ceribelli A","Lizier M","Baldanti F","Antozzi C","Gili S","Stanghellini MTL","Morrone A","Gramigna G","Notari S","Tartaglia E","Goletti D","Carsetti R","Mortarini R","Papa E","Uccelli A","Mengarelli A","Apolone G","Lapucci C","Quintarelli C","Bettini A","Mantovani A","Sinno V","Guberti M","de Braud F","Lazzarotto T","Catalano G","Tufaro A","Meschi S","Piaggio G","Tommasino M","Pinter GL","Damian S","Cimini E","Genova C","Silvestris N","Fenoglio D","Cristofanelli F","Poire I","Cassaniti I","Costantini M","Miano M","VAX4FRAIL study Group","Massafra R","Dal Bello MG","Rescigno M","Minuti GPEG","Delcuratolo S","Bruno A","Giannarelli D","Pinto C","Corazza S","Fusconi M","Montecucco CM","Graceffa D","Pulice I","Ogliari F","Monti S","Colavita F","Elena R","Bertuzzi A","Mandoj C","Locatelli F","Corradini P","Croci S","Baggi F","Inglese M","Bonifazi F","Lapa D","Valzania F","Mariotti D","Selmi C","Bordoni V","Maggi L","Sacchi A","De Santis M","Marasco V","Pronzato P","Carlo-Stella C","Puro E","Grassi G","Bortone F","Zinzani PL","Lupo-Stanghellini MT"],"additional_accession":[]},"is_claimable":false,"name":"Neutralizing antibodies to Omicron after the fourth SARS-CoV-2 mRNA vaccine dose in immunocompromised patients highlight the need of additional boosters.","description":"<h4>Introduction</h4>Immunocompromised patients have been shown to have an impaired immune response to COVID-19 vaccines.<h4>Methods</h4>Here we compared the B-cell, T-cell and neutralizing antibody response to WT and Omicron BA.2 SARS-CoV-2 virus after the fourth dose of mRNA COVID-19 vaccines in patients with hematological malignancies (HM, n=71), solid tumors (ST, n=39) and immune-rheumatological (IR, n=25) diseases. The humoral and T-cell responses to SARS-CoV-2 vaccination were analyzed by quantifying the anti-RBD antibodies, their neutralization activity and the IFN-γ released after spike specific stimulation.<h4>Results</h4>We show that the T-cell response is similarly boosted by the fourth dose across the different subgroups, while the antibody response is improved only in patients","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-07-14T21:07:26.947Z","creation":"2025-04-06T07:57:16.361Z"},"accession":"S-EPMC9911671","cross_references":{"pubmed":["36776853"],"doi":["10.3389/fimmu.2023.1104124"]}}