{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao Q"],"funding":["NCI NIH HHS","U.S. Department of Health &amp; Human Services | National Institutes of Health"],"pagination":["735"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9911733"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Although tissue-resident memory T (T<sub>RM</sub>) cells specific for previously encountered pathogens have been characterized, the induction and recruitment of brain T<sub>RM</sub> cells following immune therapy has not been observed in the context of glioblastoma. Here, we show that T cells expressing fibrinogen-like 2 (FGL2)-specific single-chain variable fragments (T-αFGL2) can induce tumor-specific CD8<sup>+</sup> T<sub>RM</sub> cells that prevent glioblastoma recurrence. These CD8<sup>+</sup> T<sub>RM</sub> cells display a highly expanded T cell receptor repertoire distinct from that found in peripheral tissue. When adoptively transferred to the brains of either immunocompetent or T cell-deficient naïve mice, these CD8<sup>+</sup> T<sub>RM</sub> cells reject glioma cells. Mechanistic"],"journal":["Nature communications"],"pubmed_title":["FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells."],"pmcid":["PMC9911733"],"funding_grant_id":["R01 CA200574"],"pubmed_authors":["Xia X","Kong L","Yan J","Heimberger AB","Fowlkes NW","Jiang S","Wang J","Li S","Hu J","Yi SF","Zhao Q","Tian X","Dao LH","Hashizume R","Jia Z","Masopust D"],"additional_accession":[]},"is_claimable":false,"name":"FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells.","description":"Although tissue-resident memory T (T<sub>RM</sub>) cells specific for previously encountered pathogens have been characterized, the induction and recruitment of brain T<sub>RM</sub> cells following immune therapy has not been observed in the context of glioblastoma. Here, we show that T cells expressing fibrinogen-like 2 (FGL2)-specific single-chain variable fragments (T-αFGL2) can induce tumor-specific CD8<sup>+</sup> T<sub>RM</sub> cells that prevent glioblastoma recurrence. These CD8<sup>+</sup> T<sub>RM</sub> cells display a highly expanded T cell receptor repertoire distinct from that found in peripheral tissue. When adoptively transferred to the brains of either immunocompetent or T cell-deficient naïve mice, these CD8<sup>+</sup> T<sub>RM</sub> cells reject glioma cells. Mechanistic","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-06-01T04:00:55.371Z","creation":"2025-06-01T04:00:55.371Z"},"accession":"S-EPMC9911733","cross_references":{"pubmed":["36759517"],"doi":["10.1038/s41467-023-36430-2"]}}