{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Tojo H"],"funding":["Ministry of Education, Culture, Sports, Science and Technology","Japan Society for the Promotion of Science"],"pubmed_abstract":["The regulation of intracellular pyrophosphate (PPi) level is crucial for proper morphogenesis across all taxonomic kingdoms. PPi is released as a byproduct from ~200 metabolic reactions, then hydrolyzed by either membrane-bound (H<sup>+</sup>-PPase) or soluble pyrophosphatases (PPases). In Arabidopsis, the loss of the vacuolar H<sup>+</sup>-PPase/FUGU5, a key enzyme in PPi homeostasis, results in delayed growth and a number of developmental defects, pointing to the importance of PPi homeostasis in plant morphogenesis. The Arabidopsis genome encodes several PPases in addition to FUGU5, such as PPsPase1/PECP2, VHP2;1 and VHP2;2, although their significance regarding PPi homeostasis remains elusive. Here, to assess their contribution, phenotypic analyses of cotyledon aspect ratio, palisade ti"],"journal":["Frontiers in plant science"],"pagination":["1031426"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9911876"],"repository":["biostudies-literature"],"pubmed_title":["Roles of type II H<sup>+</sup>-PPases and PPsPase1/PECP2 in early developmental stages and PPi homeostasis of <i>Arabidopsis thaliana</i>."],"pmcid":["PMC9911876"],"pubmed_authors":["Hirai MY","Gunji S","David P","Ferjani A","Tabeta H","Javot H","Tojo H"],"additional_accession":[]},"is_claimable":false,"name":"Roles of type II H<sup>+</sup>-PPases and PPsPase1/PECP2 in early developmental stages and PPi homeostasis of <i>Arabidopsis thaliana</i>.","description":"The regulation of intracellular pyrophosphate (PPi) level is crucial for proper morphogenesis across all taxonomic kingdoms. PPi is released as a byproduct from ~200 metabolic reactions, then hydrolyzed by either membrane-bound (H<sup>+</sup>-PPase) or soluble pyrophosphatases (PPases). In Arabidopsis, the loss of the vacuolar H<sup>+</sup>-PPase/FUGU5, a key enzyme in PPi homeostasis, results in delayed growth and a number of developmental defects, pointing to the importance of PPi homeostasis in plant morphogenesis. The Arabidopsis genome encodes several PPases in addition to FUGU5, such as PPsPase1/PECP2, VHP2;1 and VHP2;2, although their significance regarding PPi homeostasis remains elusive. Here, to assess their contribution, phenotypic analyses of cotyledon aspect ratio, palisade ti","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-04-08T14:16:13.743Z","creation":"2025-02-19T02:23:59.282Z"},"accession":"S-EPMC9911876","cross_references":{"pubmed":["36778688"],"doi":["10.3389/fpls.2023.1031426"]}}