biostudies-literatureUnknown14(1)Diaz-Valenzuela E<h4>Background</h4>Plant domestication is a remarkable example of rapid phenotypic transformation of polygenic traits, such as organ size. Evidence from a handful of study cases suggests this transformation is due to gene regulatory changes that result in non-additive phenotypes. Employing data from published genetic crosses, we estimated the role of non-additive gene action in the modulation of transcriptional landscapes in three domesticated plants: maize, sunflower, and chili pepper. Using A. thaliana, we assessed the correlation between gene regulatory network (GRN) connectivity properties, transcript abundance variation, and gene action. Finally, we investigated the propagation of non-additive gene action in GRNs.<h4>Results</h4>We compared crosses between domesticated plants and theiEvoDevo3https://www.ebi.ac.uk/biostudies/studies/S-EPMC9912502biostudies-literatureThe role of non-additive gene action on gene expression variation in plant domestication.PMC9912502Hernandez-Rios DDiaz-Valenzuela ECibrian-Jaramillo AfalseThe role of non-additive gene action on gene expression variation in plant domestication.<h4>Background</h4>Plant domestication is a remarkable example of rapid phenotypic transformation of polygenic traits, such as organ size. Evidence from a handful of study cases suggests this transformation is due to gene regulatory changes that result in non-additive phenotypes. Employing data from published genetic crosses, we estimated the role of non-additive gene action in the modulation of transcriptional landscapes in three domesticated plants: maize, sunflower, and chili pepper. Using A. thaliana, we assessed the correlation between gene regulatory network (GRN) connectivity properties, transcript abundance variation, and gene action. Finally, we investigated the propagation of non-additive gene action in GRNs.<h4>Results</h4>We compared crosses between domesticated plants and thei2023-01-01T00:00:00Z2023 Feb2026-05-28T13:56:28.917Z2024-11-20T02:07:01.071ZS-EPMC99125023676538210.1186/s13227-022-00206-4