{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zilovic D"],"funding":["Lithuanian National Cancer institute research fund."],"pagination":["868"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9913062"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(3)"],"pubmed_abstract":["<h4>Background</h4>Type II ovarian cancer (OC) is generally diagnosed at an advanced stage, translating into a poor survival rate. Current screening methods for OC have failed to demonstrate a reduction in mortality. The uterine lavage technique has been used to detect tumor-specific <i>TP53</i> mutations from cells presumably shed from high-grade serous ovarian cancer (HGSOC). We aimed to pilot whether the detection of <i>TP53</i> mutation in uterine cavity lavage can be used as a diagnostic method for HGSOC using an expanded gene panel.<h4>Methods</h4>In this study 90, uterine lavage and 46 paired biopsy samples were analyzed using next-generation sequencing (NGS) targeting <i>TP53</i> as well as five additional OC-related genes: <i>BRCA1</i>, <i>BRCA2</i>, <i>PI3KCA</i>, <i>PTEN</i>, an"],"journal":["Cancers"],"pubmed_title":["Uterine Cavity Lavage Mutation Analysis in Lithuanian Ovarian Cancer Patients."],"pmcid":["PMC9913062"],"funding_grant_id":["Lithuanian National Cancer institute research fund."],"pubmed_authors":["Zilovic D","Ciurliene R","Jarmalaite S","Sabaliauskaite R","Vaicekauskaite I"],"additional_accession":[]},"is_claimable":false,"name":"Uterine Cavity Lavage Mutation Analysis in Lithuanian Ovarian Cancer Patients.","description":"<h4>Background</h4>Type II ovarian cancer (OC) is generally diagnosed at an advanced stage, translating into a poor survival rate. Current screening methods for OC have failed to demonstrate a reduction in mortality. The uterine lavage technique has been used to detect tumor-specific <i>TP53</i> mutations from cells presumably shed from high-grade serous ovarian cancer (HGSOC). We aimed to pilot whether the detection of <i>TP53</i> mutation in uterine cavity lavage can be used as a diagnostic method for HGSOC using an expanded gene panel.<h4>Methods</h4>In this study 90, uterine lavage and 46 paired biopsy samples were analyzed using next-generation sequencing (NGS) targeting <i>TP53</i> as well as five additional OC-related genes: <i>BRCA1</i>, <i>BRCA2</i>, <i>PI3KCA</i>, <i>PTEN</i>, an","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T11:10:33.735Z","creation":"2025-04-04T11:10:33.735Z"},"accession":"S-EPMC9913062","cross_references":{"pubmed":["36765826"],"doi":["10.3390/cancers15030868"]}}