{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sojan JM"],"funding":["European community MSCA-ITN project BioMedAqu Horizon 2020"],"pagination":["364"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9913848"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["Several in vivo trials have previously demonstrated the beneficial effects of the administration of various probiotic forms on bone health. In this study, we explored the potency of two probiotics, <i>Bacillus subtilis</i> and <i>Lactococcus lactis</i>, alone or in combination with vitamin D (VD), to modulate the transcription of genes involved in the ossification process in a human osteoblast cell line. Genes that mark the \"osteoblast proliferation phase\", such as <i>RUNX2</i>, <i>TGFB1</i>, and <i>ALPL</i>, \"extracellular matrix (ECM) maturation\", such as <i>SPP1</i> and <i>SPARC</i>, as well as \"ECM mineralization\", such as <i>BGN</i>, <i>BGLAP</i>, and <i>DCN</i>, were all highly expressed in osteoblasts treated with <i>B. subtilis</i> extract. The observed increase in the transcriptio"],"journal":["Cells"],"pubmed_title":["<i>Bacillus subtilis</i> Modulated the Expression of Osteogenic Markers in a Human Osteoblast Cell Line."],"pmcid":["PMC9913848"],"funding_grant_id":["No 766347"],"pubmed_authors":["Licini C","Marcheggiani F","Carnevali O","Sojan JM","Maradonna F","Tiano L","Mattioli-Belmonte M"],"additional_accession":[]},"is_claimable":false,"name":"<i>Bacillus subtilis</i> Modulated the Expression of Osteogenic Markers in a Human Osteoblast Cell Line.","description":"Several in vivo trials have previously demonstrated the beneficial effects of the administration of various probiotic forms on bone health. In this study, we explored the potency of two probiotics, <i>Bacillus subtilis</i> and <i>Lactococcus lactis</i>, alone or in combination with vitamin D (VD), to modulate the transcription of genes involved in the ossification process in a human osteoblast cell line. Genes that mark the \"osteoblast proliferation phase\", such as <i>RUNX2</i>, <i>TGFB1</i>, and <i>ALPL</i>, \"extracellular matrix (ECM) maturation\", such as <i>SPP1</i> and <i>SPARC</i>, as well as \"ECM mineralization\", such as <i>BGN</i>, <i>BGLAP</i>, and <i>DCN</i>, were all highly expressed in osteoblasts treated with <i>B. subtilis</i> extract. The observed increase in the transcriptio","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-06-01T03:58:53.123Z","creation":"2024-11-19T19:02:32.748Z"},"accession":"S-EPMC9913848","cross_references":{"pubmed":["36766709"],"doi":["10.3390/cells12030364"]}}