{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Zhang P"],"funding":["NIGMS NIH HHS"],"pubmed_abstract":["Apical constriction is a cell shape change that drives key morphogenetic events during development, including gastrulation and neural tube formation. The forces driving apical constriction are primarily generated through the contraction of apicolateral and/or medioapical actomyosin networks. In the <i>Drosophila</i> ventral furrow, the medioapical actomyosin network has a sarcomere-like architecture, with radially polarized actin filaments and centrally enriched non-muscle myosin II and myosin activating kinase. To determine if this is a broadly conserved actin architecture driving apical constriction, we examined actomyosin architecture during <i>C. elegans</i> gastrulation, in which two endodermal precursor cells internalize from the surface of the embryo. Quantification of protein local"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.01.30.526280"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9915510"],"repository":["biostudies-literature"],"pubmed_title":["Architecture of the cortical actomyosin network driving apical constriction in <i>C. elegans</i>."],"pmcid":["PMC9915510"],"funding_grant_id":["R35 GM134838"],"pubmed_authors":["Medwig-Kinney TN","Goldstein B","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"Architecture of the cortical actomyosin network driving apical constriction in <i>C. elegans</i>.","description":"Apical constriction is a cell shape change that drives key morphogenetic events during development, including gastrulation and neural tube formation. The forces driving apical constriction are primarily generated through the contraction of apicolateral and/or medioapical actomyosin networks. In the <i>Drosophila</i> ventral furrow, the medioapical actomyosin network has a sarcomere-like architecture, with radially polarized actin filaments and centrally enriched non-muscle myosin II and myosin activating kinase. To determine if this is a broadly conserved actin architecture driving apical constriction, we examined actomyosin architecture during <i>C. elegans</i> gastrulation, in which two endodermal precursor cells internalize from the surface of the embryo. Quantification of protein local","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-08-15T03:05:45.635Z","creation":"2025-04-05T18:36:05.419Z"},"accession":"S-EPMC9915510","cross_references":{"pubmed":["36778218"],"doi":["10.1101/2023.01.30.526280"]}}