{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Gupta S"],"funding":["NIGMS NIH HHS"],"pubmed_abstract":["Nanoparticles, such as viruses, can enter cells via endocytosis. During endocytosis, the cell surface wraps around the nanoparticle to effectively eat it. Prior focus has been on how nanoparticle size and shape impacts endocytosis. However, inspired by the noted presence of extracellular vimentin affecting viral and bacteria uptake, as well as the structure of coronaviruses, we construct a computational model in which <i>both</i> the cell-like construct and the virus-like construct contain filamentous protein structures protruding from their surfaces. We then study the impact of these additional degrees of freedom on viral wrapping. We find that cells with an optimal density of filamentous extracellular components (ECCs) are more likely to be infected as they uptake the virus faster and us"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.01.30.526272"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9915516"],"repository":["biostudies-literature"],"pubmed_title":["How cells wrap around virus-like particles using extracellular filamentous protein structures."],"pmcid":["PMC9915516"],"funding_grant_id":["R35 GM142963"],"pubmed_authors":["Patteson AE","Gupta S","Schwarz JM","Santangelo CD"],"additional_accession":[]},"is_claimable":false,"name":"How cells wrap around virus-like particles using extracellular filamentous protein structures.","description":"Nanoparticles, such as viruses, can enter cells via endocytosis. During endocytosis, the cell surface wraps around the nanoparticle to effectively eat it. Prior focus has been on how nanoparticle size and shape impacts endocytosis. However, inspired by the noted presence of extracellular vimentin affecting viral and bacteria uptake, as well as the structure of coronaviruses, we construct a computational model in which <i>both</i> the cell-like construct and the virus-like construct contain filamentous protein structures protruding from their surfaces. We then study the impact of these additional degrees of freedom on viral wrapping. We find that cells with an optimal density of filamentous extracellular components (ECCs) are more likely to be infected as they uptake the virus faster and us","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-08-24T03:08:40.929Z","creation":"2025-08-24T03:08:40.929Z"},"accession":"S-EPMC9915516","cross_references":{"pubmed":["36778225"],"doi":["10.1101/2023.01.30.526272"]}}